NDLI: Novel Insight into Mutational Landscape of Head and Neck Squamous Cell Carcinoma

Content Provider	PubMed Central
Author	Gaykalova, Daria A. Mambo, Elizabeth Choudhary, Ashish Houghton, Jeffery Kalyan, Buddavarapu Sanford, Tiffany Darden, Will Alex, Adai Hadd, Andrew Latham, Gary Danilova, Ludmila V. Bishop, Justin Li, Ryan J. Westra, William H. Hennessey, Patrick Koch, Wayne M. Ochs, Michael F. Califano, Joseph A. Sun, Wenyue
Editor	Amin, A. R. M. Ruhul
Copyright Year	2014
Abstract	Development of head and neck squamous cell carcinoma (HNSCC) is characterized by accumulation of mutations in several oncogenes and tumor suppressor genes. We have formerly described the mutation pattern of HNSCC and described NOTCH signaling pathway alterations. Given the complexity of the HNSCC, here we extend the previous study to understand the overall HNSCC mutation context and to discover additional genetic alterations. We performed high depth targeted exon sequencing of 51 highly actionable cancer-related genes with a high frequency of mutation across many cancer types, including head and neck. DNA from primary tumor tissues and matched normal tissues was analyzed for 37 HNSCC patients. We identified 26 non-synonymous or stop-gained mutations targeting 11 of 51 selected genes. These genes were mutated in 17 out of 37 (46%) studied HNSCC patients. Smokers harbored 3.2-fold more mutations than non-smokers. Importantly, TP53 was mutated in 30%, NOTCH1 in 8% and FGFR3 in 5% of HNSCC. HPV negative patients harbored 4-fold more TP53 mutations than HPV positive patients. These data confirm prior reports of the HNSCC mutational profile. Additionally, we detected mutations in two new genes, CEBPA and FES, which have not been previously reported in HNSCC. These data extend the spectrum of HNSCC mutations and define novel mutation targets in HNSCC carcinogenesis, especially for smokers and HNSCC without HPV infection.
Related Links	http://dx.doi.org/10.1371/journal.pone.0093102
Starting Page	93102
File Format	PDF
ISSN	19326203
e-ISSN	19326203
Journal	PLoS ONE
Issue Number	3
Volume Number	9
Language	English
Publisher	Public Library of Science
Publisher Date	2014-03-25
Access Restriction	Open
Rights Holder	Public Library of Science
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

The Mutational Landscape of Head and Neck Squamous Cell Carcinoma

Mutational landscape of head and neck squamous cell carcinomas in a South Asian population

The mutational landscape of head and neck squamous cell carcinoma.

Analysis of Mutational Profile of Hypopharyngeal and Laryngeal Head and Neck Squamous Cell Carcinomas Identifies KMT2C as a Potential Tumor Suppressor

A Novel Immune-Related Prognostic Signature in Head and Neck Squamous Cell Carcinoma

A new insight into the diverse facets of microRNA-31 in oral squamous cell carcinoma

Development of an Immunogenomic Landscape-Based Prognostic Index of Head and Neck Squamous Cell Carcinoma

The Landscape of Somatic Copy Number Alterations in Head and Neck Squamous Cell Carcinoma

Genetic landscape of metastatic and recurrent head and neck squamous cell carcinoma

Novel Insight into Mutational Landscape of Head and Neck Squamous Cell Carcinoma

Similar Documents

The Mutational Landscape of Head and Neck Squamous Cell Carcinoma

Mutational landscape of head and neck squamous cell carcinomas in a South Asian population

The mutational landscape of head and neck squamous cell carcinoma.

Analysis of Mutational Profile of Hypopharyngeal and Laryngeal Head and Neck Squamous Cell Carcinomas Identifies KMT2C as a Potential Tumor Suppressor

A Novel Immune-Related Prognostic Signature in Head and Neck Squamous Cell Carcinoma

A new insight into the diverse facets of microRNA-31 in oral squamous cell carcinoma

Development of an Immunogenomic Landscape-Based Prognostic Index of Head and Neck Squamous Cell Carcinoma

The Landscape of Somatic Copy Number Alterations in Head and Neck Squamous Cell Carcinoma

Genetic landscape of metastatic and recurrent head and neck squamous cell carcinoma

Novel Insight into Mutational Landscape of Head and Neck Squamous Cell Carcinoma