NDLI: TrueAllele Casework on Virginia DNA Mixture Evidence: Computer and Manual Interpretation in 72 Reported Criminal Cases

Content Provider	PubMed Central
Author	Perlin, Mark W. Dormer, Kiersten Hornyak, Jennifer Lisa, Schiermeier-wood Greenspoon, Susan
Editor	Ballantyne, Jack
Copyright Year	2014
Abstract	Mixtures are a commonly encountered form of biological evidence that contain DNA from two or more contributors. Laboratory analysis of mixtures produces data signals that usually cannot be separated into distinct contributor genotypes. Computer modeling can resolve the genotypes up to probability, reflecting the uncertainty inherent in the data. Human analysts address the problem by simplifying the quantitative data in a threshold process that discards considerable identification information. Elevated stochastic threshold levels potentially discard more information. This study examines three different mixture interpretation methods. In 72 criminal cases, 111 genotype comparisons were made between 92 mixture items and relevant reference samples. TrueAllele computer modeling was done on all the evidence samples, and documented in DNA match reports that were provided as evidence for each case. Threshold-based Combined Probability of Inclusion (CPI) and stochastically modified CPI (mCPI) analyses were performed as well. TrueAllele’s identification information in 101 positive matches was used to assess the reliability of its modeling approach. Comparison was made with 81 CPI and 53 mCPI DNA match statistics that were manually derived from the same data. There were statistically significant differences between the DNA interpretation methods. TrueAllele gave an average match statistic of 113 billion, CPI averaged 6.68 million, and mCPI averaged 140. The computer was highly specific, with a false positive rate under 0.005%. The modeling approach was precise, having a factor of two within-group standard deviation. TrueAllele accuracy was indicated by having uniformly distributed match statistics over the data set. The computer could make genotype comparisons that were impossible or impractical using manual methods. TrueAllele computer interpretation of DNA mixture evidence is sensitive, specific, precise, accurate and more informative than manual interpretation alternatives. It can determine DNA match statistics when threshold-based methods cannot. Improved forensic science computation can affect criminal cases by providing reliable scientific evidence.
Related Links	http://dx.doi.org/10.1371/journal.pone.0092837
Starting Page	92837
File Format	PDF
ISSN	19326203
e-ISSN	19326203
Journal	PLoS ONE
Issue Number	3
Volume Number	9
Language	English
Publisher	Public Library of Science
Publisher Date	2014-03-01
Access Restriction	Open
Rights Holder	Public Library of Science
Subject Keyword	Biochemistry, Genetics and Molecular Biology(all) Agricultural and Biological Sciences(all) Medicine(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

The Admissibility of TrueAllele: A Computerized DNA Interpretation System

An Information Gap in DNA Evidence Interpretation

Exploring the Seasonality of Reported Treated Malaria Cases in Mpumalanga, South Africa

First Reported Cases of Biomechanically Adaptive Bone Modeling in Non-Avian Dinosaurs

Correction: Chronic Traumatic Encephalopathy in Contact Sports: A Systematic Review of All Reported Pathological Cases

Persistence of DNA in Carcasses, Slime and Avian Feces May Affect Interpretation of Environmental DNA Data

On the Genetic Interpretation of Disease Data

Phylogenetic mixture models for proteins

Indirect and direct evidence for DNA double-strand breaks in hypermutating immunoglobulin genes.

TrueAllele Casework on Virginia DNA Mixture Evidence: Computer and Manual Interpretation in 72 Reported Criminal Cases

Similar Documents

The Admissibility of TrueAllele: A Computerized DNA Interpretation System

An Information Gap in DNA Evidence Interpretation

Exploring the Seasonality of Reported Treated Malaria Cases in Mpumalanga, South Africa

First Reported Cases of Biomechanically Adaptive Bone Modeling in Non-Avian Dinosaurs

Correction: Chronic Traumatic Encephalopathy in Contact Sports: A Systematic Review of All Reported Pathological Cases

Persistence of DNA in Carcasses, Slime and Avian Feces May Affect Interpretation of Environmental DNA Data

On the Genetic Interpretation of Disease Data

Phylogenetic mixture models for proteins

Indirect and direct evidence for DNA double-strand breaks in hypermutating immunoglobulin genes.

TrueAllele Casework on Virginia DNA Mixture Evidence: Computer and Manual Interpretation in 72 Reported Criminal Cases