NDLI: Changes in Mouse Thymus and Spleen after Return from the STS-135 Mission in Space

Content Provider	PubMed Central
Author	Gridley, Daila S. Mao, Xiao Wen Stodieck, Louis S. Ferguson, Virginia L. Bateman, Ted A. Moldovan, Maria Cunningham, Christopher E. Jones, Tamako A. Slater, Jerry M. Pecaut, Michael J.
Editor	Singh, Kamaleshwar
Copyright Year	2013
Abstract	Our previous results with flight (FLT) mice showed abnormalities in thymuses and spleens that have potential to compromise immune defense mechanisms. In this study, the organs were further evaluated in C57BL/6 mice after Space Shuttle Atlantis returned from a 13-day mission. Thymuses and spleens were harvested from FLT mice and ground controls housed in similar animal enclosure modules (AEM). Organ and body mass, DNA fragmentation and expression of genes related to T cells and cancer were determined. Although significance was not obtained for thymus mass, DNA fragmentation was greater in the FLT group (P<0.01). Spleen mass alone and relative to body mass was significantly decreased in FLT mice (P<0.05). In FLT thymuses, 6/84 T cell-related genes were affected versus the AEM control group (P<0.05; up: IL10, Il18bp, Il18r1, Spp1; down: Ccl7, IL6); 15/84 cancer-related genes had altered expression (P<0.05; up: Casp8, FGFR2, Figf, Hgf, IGF1, Itga4, Ncam1, Pdgfa, Pik3r1, Serpinb2, Sykb; down: Cdc25a, E2F1, Mmp9, Myc). In the spleen, 8/84 cancer-related genes were affected in FLT mice compared to AEM controls (P<0.05; up: Cdkn2a; down: Birc5, Casp8, Ctnnb1, Map2k1, Mdm2, NFkB1, Pdgfa). Pathway analysis (apoptosis signaling and checkpoint regulation) was used to map relationships among the cancer–related genes. The results showed that a relatively short mission in space had a significant impact on both organs. The findings also indicate that immune system aberrations due to stressors associated with space travel should be included when estimating risk for pathologies such as cancer and infection and in designing appropriate countermeasures. Although this was the historic last flight of NASA’s Space Shuttle Program, exploration of space will undoubtedly continue.
Related Links	http://dx.doi.org/10.1371/journal.pone.0075097
Starting Page	75097
File Format	PDF
ISSN	19326203
e-ISSN	19326203
Journal	PLoS ONE
Issue Number	9
Volume Number	8
Language	English
Publisher	Public Library of Science
Publisher Date	2013-09-01
Access Restriction	Open
Rights Holder	Public Library of Science
Subject Keyword	Biochemistry, Genetics and Molecular Biology(all) Agricultural and Biological Sciences(all) Medicine(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Correction: Changes in Mouse Thymus and Spleen after Return from the STS-135 Mission in Space

Changes in Mouse Thymus and Spleen after Return from the STS-135 Mission in Space

Changes in mouse thymus and spleen after return from the STS-135 mission in space.

Correction: Changes in Mouse Thymus and Spleen after Return from the STS-135 Mission in Space.

Post-Spaceflight (STS-135) Mouse Splenocytes Demonstrate Altered Activation Properties and Surface Molecule Expression

RNA Sequence Reveals Mouse Retinal Transcriptome Changes Early after Axonal Injury

Induced Prion Protein Controls Immune-Activated Retroviruses in the Mouse Spleen

Rapid Changes in Cortical and Subcortical Brain Regions after Early Bilateral Enucleation in the Mouse

Long-Term Differential Changes in Mouse Intestinal Metabolomics after γ and Heavy Ion Radiation Exposure

Changes in Mouse Thymus and Spleen after Return from the STS-135 Mission in Space

Similar Documents

Correction: Changes in Mouse Thymus and Spleen after Return from the STS-135 Mission in Space

Changes in Mouse Thymus and Spleen after Return from the STS-135 Mission in Space

Changes in mouse thymus and spleen after return from the STS-135 mission in space.

Correction: Changes in Mouse Thymus and Spleen after Return from the STS-135 Mission in Space.

Post-Spaceflight (STS-135) Mouse Splenocytes Demonstrate Altered Activation Properties and Surface Molecule Expression

RNA Sequence Reveals Mouse Retinal Transcriptome Changes Early after Axonal Injury

Induced Prion Protein Controls Immune-Activated Retroviruses in the Mouse Spleen

Rapid Changes in Cortical and Subcortical Brain Regions after Early Bilateral Enucleation in the Mouse

Long-Term Differential Changes in Mouse Intestinal Metabolomics after γ and Heavy Ion Radiation Exposure

Changes in Mouse Thymus and Spleen after Return from the STS-135 Mission in Space