NDLI: Foster Dams Rear Fighters: Strain-Specific Effects of Within-Strain Fostering on Aggressive Behavior in Male Mice

Content Provider	PubMed Central
Author	Cox, Kimberly H. So, Nina L. T. Rissman, Emilie F.
Editor	Crusio, Wim E.
Copyright Year	2013
Abstract	It is well known that genes and environment interact to produce behavioral phenotypes. One environmental factor with long-term effects on gene transcription and behavior is maternal care. A classic paradigm for examining maternal care and genetic interactions is to foster pups of one genetic strain to dams of a different strain ("between-strain fostering"). In addition, fostering to a dam of the same strain ("within-strain fostering") is used to reduce indirect effects, via behavioral changes in the dams, of gestation treatments on offspring. Using within-and between-strain fostering we examined the contributions of genetics/prenatal environment, maternal care, and the effects of fostering per se, on adult aggressive behavior in two inbred mouse strains, C57BL/6J (B6) and DBA/2J (DBA). We hypothesized that males reared by dams of the more aggressive DBA strain would attack intruders faster than those reared by B6 dams. Surprisingly, we found that both methods of fostering enhanced aggressive behavior, but only in B6 mice. Since all the B6 offspring are genetically identical, we asked if maternal behavior of B6 dams was affected by the relatedness of their pups. In fact, B6 dams caring for foster B6 pups displayed significantly reduced maternal behaviors. Finally, we measured vasopressin and corticotrophin releasing hormone mRNA in the amygdalae of adult B6 males reared by foster or biological dams. Both genes correlated with aggressive behavior in within-strain fostered B6 mice, but not in mice reared by their biological dams. In sum, we have demonstrated in inbred laboratory mice, that dams behave differently when rearing their own newborn pups versus pups from another dam of the same strain. These differences in maternal care affect aggression in the male offspring and transcription of Avp and Crh in the brain. It is likely that rearing by foster dams has additional effects and implications for other species.
Related Links	http://dx.doi.org/10.1371/journal.pone.0075037
Starting Page	75037
File Format	PDF
ISSN	19326203
e-ISSN	19326203
Journal	PLoS ONE
Issue Number	9
Volume Number	8
Language	English
Publisher	Public Library of Science
Publisher Date	2013-09-01
Access Restriction	Open
Rights Holder	Public Library of Science
Subject Keyword	Biochemistry, Genetics and Molecular Biology(all) Agricultural and Biological Sciences(all) Medicine(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Cross-Fostering of Male Mice Subtly Affects Female Olfactory Preferences

Frustrative reward omission increases aggressive behaviour of inferior fighters

Cross Fostering Experiments Suggest That Mice Songs Are Innate

Wolbachia Induces Male-Specific Mortality in the Mosquito Culex pipiens (LIN Strain)

Site and Strain-Specific Variation in Gut Microbiota Profiles and Metabolism in Experimental Mice

Effects of Sevoflurane on Young Male Adult C57BL/6 Mice Spatial Cognition

Sex Differences in Thermogenesis Structure Behavior and Contact within Huddles of Infant Mice

Change in maternal environment induced by cross-fostering alters genetic and epigenetic effects on complex traits in mice

Osteoblast-Specific Krm2 Overexpression and Lrp5 Deficiency Have Different Effects on Fracture Healing in Mice

Foster Dams Rear Fighters: Strain-Specific Effects of Within-Strain Fostering on Aggressive Behavior in Male Mice

Similar Documents

Cross-Fostering of Male Mice Subtly Affects Female Olfactory Preferences

Frustrative reward omission increases aggressive behaviour of inferior fighters

Cross Fostering Experiments Suggest That Mice Songs Are Innate

Wolbachia Induces Male-Specific Mortality in the Mosquito Culex pipiens (LIN Strain)

Site and Strain-Specific Variation in Gut Microbiota Profiles and Metabolism in Experimental Mice

Effects of Sevoflurane on Young Male Adult C57BL/6 Mice Spatial Cognition

Sex Differences in Thermogenesis Structure Behavior and Contact within Huddles of Infant Mice

Change in maternal environment induced by cross-fostering alters genetic and epigenetic effects on complex traits in mice

Osteoblast-Specific Krm2 Overexpression and Lrp5 Deficiency Have Different Effects on Fracture Healing in Mice

Foster Dams Rear Fighters: Strain-Specific Effects of Within-Strain Fostering on Aggressive Behavior in Male Mice