NDLI: Unraveling the Evolution of the Atlantic Cod’s (Gadus morhua L.) Alternative Immune Strategy

Content Provider	PubMed Central
Author	Martin, MalmstrÃ¸m Jentoft, Sissel Gregers, Tone F. Jakobsen, Kjetill S.
Editor	Allen, Rachel Louise
Copyright Year	2013
Abstract	Genes encoding the major histocompatibility complex (MHC) have been thought to play a vital role in the adaptive immune system in all vertebrates. The discovery that Atlantic cod (Gadus morhua) has lost important components of the MHC II pathway, accompanied by an unusually high number of MHC I genes, shed new light on the evolution and plasticity of the immune system of teleosts as well as in higher vertebrates. The overall aim of this study was to further investigate the highly expanded repertoire of MHC I genes using a cDNA approach to obtain sequence information of both the binding domains and the sorting signaling potential in the cytoplasmic tail. Here we report a novel combination of two endosomal sorting motifs, one tyrosine-based associated with exogenous peptide presentation by cross-presenting MHCI molecules, and one dileucine-based associated with normal MHC II functionality. The two signal motifs were identified in the cytoplasmic tail in a subset of the genes. This indicates that these genes have evolved MHC II-like functionality, allowing a more versatile use of MHC I through cross-presentation. Such an alternative immune strategy may have arisen through adaptive radiation and acquisition of new gene function as a response to changes in the habitat of its ancestral lineage.
Related Links	http://dx.doi.org/10.1371/journal.pone.0074004
Starting Page	74004
File Format	PDF
ISSN	19326203
e-ISSN	19326203
Journal	PLoS ONE
Issue Number	9
Volume Number	8
Language	English
Publisher	Public Library of Science
Publisher Date	2013-09-01
Access Restriction	Open
Rights Holder	Public Library of Science
Subject Keyword	Biochemistry, Genetics and Molecular Biology(all) Agricultural and Biological Sciences(all) Medicine(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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Correction: Unraveling the Evolution of the Atlantic Cod’s (Gadus morhua L.) Alternative Immune Strategy

Physiological and Behavioural Responses to Noxious Stimuli in the Atlantic Cod (Gadus morhua)

Factors Regulating Early Life History Dispersal of Atlantic Cod (Gadus morhua) from Coastal Newfoundland

Effects of Hypoxic Exposure during Feeding on SDA and Postprandial Cardiovascular Physiology in the Atlantic Cod, Gadus morhua

Effect of Sub-Lethal Exposure to Ultraviolet Radiation on the Escape Performance of Atlantic Cod Larvae (Gadus morhua)

Effects of turbidity on the spontaneous and prey-searching activity of juvenile Atlantic cod (Gadus morhua)

Iodine nutrition and toxicity in Atlantic cod (Gadus morhua) larvae

Discrimination between Weaned and Unweaned Atlantic Cod (Gadus morhua) in Capture-Based Aquaculture (CBA) by X-Ray Imaging and Radio-Frequency Metal Detector

Countergradient variation in body shape between two populations of Atlantic cod (Gadus morhua)

Unraveling the Evolution of the Atlantic Cod’s (Gadus morhua L.) Alternative Immune Strategy

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Correction: Unraveling the Evolution of the Atlantic Cod’s (Gadus morhua L.) Alternative Immune Strategy

Physiological and Behavioural Responses to Noxious Stimuli in the Atlantic Cod (Gadus morhua)

Factors Regulating Early Life History Dispersal of Atlantic Cod (Gadus morhua) from Coastal Newfoundland

Effects of Hypoxic Exposure during Feeding on SDA and Postprandial Cardiovascular Physiology in the Atlantic Cod, Gadus morhua

Effect of Sub-Lethal Exposure to Ultraviolet Radiation on the Escape Performance of Atlantic Cod Larvae (Gadus morhua)

Effects of turbidity on the spontaneous and prey-searching activity of juvenile Atlantic cod (Gadus morhua)

Iodine nutrition and toxicity in Atlantic cod (Gadus morhua) larvae

Discrimination between Weaned and Unweaned Atlantic Cod (Gadus morhua) in Capture-Based Aquaculture (CBA) by X-Ray Imaging and Radio-Frequency Metal Detector

Countergradient variation in body shape between two populations of Atlantic cod (Gadus morhua)

Unraveling the Evolution of the Atlantic Cod’s (Gadus morhua L.) Alternative Immune Strategy