NDLI: Discovery and verification of panels of T-lymphocyte proteins as biomarkers of Parkinson's disease

Content Provider	PubMed Central
Author	Alberio, Tiziana Pippione, Agnese C. Maurizio, Zibetti Olgiati, Simone Cecconi, Daniela Comi, Cristoforo Leonardo, Lopiano Fasano, Mauro
Copyright Year	2012
Abstract	The diagnosis of Parkinson's disease (PD) is currently based on the clinical evaluation of extrapyramidal signs with a considerable error rate. The identification of specific markers might allow PD diagnosis before the onset of classical motor symptoms. By two-dimensional electrophoresis we identified proteome alterations in T-lymphocytes of 17 control subjects and 15 PD patients. The observed changes were used to build predictive models that were verified by the leave-one-out cross-validation. We further built two functions able to stage the subjects. We chose to verify by Western blotting the identity of spots corresponding to β-fibrinogen and transaldolase, two recurrent proteins in six out of 20 spots. β-Fibrinogen levels are lowered in PD patients, whereas a heavy transaldolase set of isoforms was more abundant. Eventually, we identified a list of seven proteins showing different levels in early-onset with respect to late-onset PD patients.
Related Links	http://dx.doi.org/10.1038/srep00953
Starting Page	953
File Format	PDF
ISSN	20452322
e-ISSN	20452322
Journal	Scientific Reports
Volume Number	2
Language	English
Publisher	Nature Publishing Group
Publisher Date	2012-12-01
Access Restriction	Open
Rights Holder	Nature Publishing Group
Subject Keyword	Science and technology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Discovery and verification of panels of T-lymphocyte proteins as biomarkers of Parkinson's disease

MicroRNA panels as disease biomarkers distinguishing hepatitis B virus infection caused hepatitis and liver cirrhosis

Parkinson's Disease Biomarkers: Resources for Discovery and Validation

DJ-1 isoforms in whole blood as potential biomarkers of Parkinson disease

α-Synuclein Reactive Antibodies as Diagnostic Biomarkers in Blood Sera of Parkinson's Disease Patients

Decreased B and T lymphocyte attenuator in Behcet’s disease may trigger abnormal Th17 and Th1 immune responses

Specific Changes of Serum Proteins in Parkinson's Disease Patients

Screening and identification of five serum proteins as novel potential biomarkers for cured pulmonary tuberculosis

A longitudinal study on α-synuclein in blood plasma as a biomarker for Parkinson's disease

Discovery and verification of panels of T-lymphocyte proteins as biomarkers of Parkinson's disease

Similar Documents

Discovery and verification of panels of T-lymphocyte proteins as biomarkers of Parkinson's disease

MicroRNA panels as disease biomarkers distinguishing hepatitis B virus infection caused hepatitis and liver cirrhosis

Parkinson's Disease Biomarkers: Resources for Discovery and Validation

DJ-1 isoforms in whole blood as potential biomarkers of Parkinson disease

α-Synuclein Reactive Antibodies as Diagnostic Biomarkers in Blood Sera of Parkinson's Disease Patients

Decreased B and T lymphocyte attenuator in Behcet’s disease may trigger abnormal Th17 and Th1 immune responses

Specific Changes of Serum Proteins in Parkinson's Disease Patients

Screening and identification of five serum proteins as novel potential biomarkers for cured pulmonary tuberculosis

A longitudinal study on α-synuclein in blood plasma as a biomarker for Parkinson's disease

Discovery and verification of panels of T-lymphocyte proteins as biomarkers of Parkinson's disease