NDLI: Hypoxia inducible factor-1α is necessary for invasive phenotype in Vegf-deleted islet cell tumors

Content Provider	PubMed Central
Author	Takeda, Takaaki Okuyama, Hiroaki Nishizawa, Yasuko Tomita, Shuhei Inoue, Masahiro
Copyright Year	2012
Abstract	In the mouse model of pancreas endocrine tumor, loss of Vegf (VKO) results in dramatically decreased tumor progression; however, the residual microscopic lesions show increased invasion into surrounding exocrine tissue. Double KO mice of Vegf and hypoxia inducible factor-1α (Hif-1α) showed increased life span and suppressed tumor growth due to increased apoptosis. The increased invasiveness of tumors in VKO mice was diminished in DKO mice to the levels of wild-type mice. Compared to VKO mice, DKO mice also exhibited smaller changes in the expression levels of adhesion molecules, including E-cadherin, N-cadherin, and NCAM. These changes of adhesion molecules were not observed in the primary culture of the tumor cells under hypoxic conditions. Thus, the invasive phenotype observed under angiogenesis inhibition requires Hif-1α, but is not directly caused by acute hypoxia.
Related Links	http://dx.doi.org/10.1038/srep00494
Starting Page	494
File Format	PDF
ISSN	20452322
e-ISSN	20452322
Journal	Scientific Reports
Volume Number	2
Language	English
Publisher	Nature Publishing Group
Publisher Date	2012-07-01
Access Restriction	Open
Rights Holder	Nature Publishing Group
Subject Keyword	Science and technology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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Hypoxia inducible factor-1α is necessary for invasive phenotype in Vegf-deleted islet cell tumors