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| Content Provider | PubMed Central |
|---|---|
| Author | Lev, Atar Simon, Amos J. Trakhtenbrot, Luba Goldstein, Itamar Nagar, Meital Polina, Stepensky Gideon, Rechavi Amariglio, Ninette Raz, Somech |
| Copyright Year | 2012 |
| Abstract | Introduction. Patients with severe combined immunodeficiency (SCID) may present with residual circulating T cells. While all cells are functionally deficient, resulting in high susceptibility to infections, only some of these cells are causing autoimmune symptoms. Methods. Here we compared T-cell functions including the number of circulating CD3+ T cells, in vitro responses to mitogens, T-cell receptor (TCR) repertoire, TCR excision circles (TREC) levels, and regulatory T cells (Tregs) enumeration in several immunodeficinecy subtypes, clinically presenting with nonreactive residual cells (MHC-II deficiency) or reactive cells. The latter includes patients with autoreactive clonal expanded T cell and patients with alloreactive transplacentally maternal T cells. Results. MHC-II deficient patients had slightly reduced T-cell function, normal TRECs, TCR repertoires, and normal Tregs enumeration. In contrast, patients with reactive T cells exhibited poor T-cell differentiation and activity. While the autoreactive cells displayed significantly reduced Tregs numbers, the alloreactive transplacentally acquired maternal lymphocytes had high functional Tregs. Conclusion. SCID patients presenting with circulating T cells show different patterns of T-cell activity and regulatory T cells enumeration that dictates the immunodeficient and autoimmune manifestations. We suggest that a high-tolerance capacity of the alloreactive transplacentally acquired maternal lymphocytes represents a toleration advantage, yet still associated with severe immunodeficiency. |
| Related Links | http://dx.doi.org/10.1155/2012/261470 |
| Starting Page | 261470 |
| File Format | |
| ISSN | 17402530 |
| e-ISSN | 17402530 |
| Journal | Clinical and Developmental Immunology |
| Volume Number | 2012 |
| Language | English |
| Publisher | Hindawi Publishing Corporation |
| Publisher Date | 2012-01-01 |
| Access Restriction | Open |
| Rights Holder | Hindawi Publishing Corporation |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
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