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| Content Provider | PubMed Central |
|---|---|
| Author | De, La Cruz-merino Luis Lejeune, Marylène Fernández, Esteban Nogales Carrasco, Fernando Henao López, Ana Grueso Vacas, Ana Illescas Pulla, Mariano Provencio Callau, Cristina Álvaro, Tomás |
| Copyright Year | 2012 |
| Abstract | Hodgkin's lymphoma represents one of the most frequent lymphoproliferative syndromes, especially in young population. Although HL is considered one of the most curable tumors, a sizeable fraction of patients recur after successful upfront treatment or, less commonly, are primarily resistant. This work tries to summarize the data on clinical, histological, pathological, and biological factors in HL, with special emphasis on the improvement of prognosis and their impact on therapeutical strategies. The recent advances in our understanding of HL biology and immunology show that infiltrated immune cells and cytokines in the tumoral microenvironment may play different functions that seem tightly related with clinical outcomes. Strategies aimed at interfering with the crosstalk between tumoral Reed-Sternberg cells and their cellular partners have been taken into account in the development of new immunotherapies that target different cell components of HL microenvironment. This new knowledge will probably translate into a change in the antineoplastic treatments in HL in the next future and hopefully will increase the curability rates of this disease. |
| Related Links | http://dx.doi.org/10.1155/2012/756353 |
| Starting Page | 756353 |
| File Format | |
| ISSN | 17402522 |
| e-ISSN | 17402530 |
| Journal | Clinical and Developmental Immunology |
| Volume Number | 2012 |
| Language | English |
| Publisher | Hindawi Publishing Corporation |
| Publisher Date | 2012-01-01 |
| Access Restriction | Open |
| Rights Holder | Hindawi Publishing Corporation |
| Subject Keyword | Immunology Immunology and Allergy Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
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