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| Content Provider | Journal of Biological Chemistry (JBC) |
|---|---|
| Author | Izawa, Ichiro Nishizawa, Miwako Ohtakara, Kazuhiro Inagaki, Masaki |
| Abstract | Densin-180, a protein purified from the postsynaptic density fraction of the rat forebrain, is the founding member of a newly described family of proteins termed the LAP (leucine-rich repeats and PSD-95/Dlg-A/ZO-1 (PDZ) domains) family that plays essential roles in establishment of cell polarity. To identify Densin-180-binding proteins, we screened a yeast two-hybrid library using the carboxyl-terminal fragment of Densin-180 containing PDZ domain as bait, and we isolated δ-catenin/neural plakophilin-related armadillo repeat protein (NPRAP) as a Densin-180-interacting protein. δ-catenin/NPRAP, a member of the armadillo repeat family, is a nervous system-specific adherens junction protein originally discovered as an interactor with presenilin-1, a protein involved in Alzheimer's disease. Densin-180 PDZ domain binds the COOH terminus of δ-catenin/NPRAP containing the PDZ domain-binding sequence. Endogenous Densin-180 was co-immunoprecipitated with δ-catenin/NPRAP and N-cadherin. Although Densin-180 was reported to be a transmembrane protein, Densin-180 was not accessible to surface biotinylation in dissociated hippocampal neurons; hence Densin-180 may be a cytosolic protein. Densin-180 co-localized with δ-catenin/NPRAP at synapses in dissociated hippocampal neurons. We propose that Densin-180 is associated in vivo with δ-catenin/NPRAP and may be involved in organization of the synaptic cell-cell junction through interaction with the δ-catenin/NPRAP-N-cadherin complex. |
| Related Links | http://www.jbc.org/content/277/7/5345.abstract |
| Ending Page | 5350 |
| Starting Page | 5345 |
| Page Count | 6 |
| File Format | HTM / HTML PDF |
| ISSN | 00219258 |
| Journal | Journal of Biological Chemistry (JBC) |
| Issue Number | 7 |
| Volume Number | 277 |
| DOI | 10.1074/jbc.M110052200 |
| e-ISSN | 1083351X |
| Language | English |
| Publisher | American Society for Biochemistry and Molecular Biology |
| Publisher Date | 2002-02-15 |
| Access Restriction | Open |
| Subject Keyword | Postsynaptic density (PSD) Ca2+/calmodulin-dependent kinase II (CaMKII) Glutathione S-transferase (GST) Histidine (His) Neural plakophilin-related armadillo repeat protein (NPRAP) Leucine-rich repeats (LAP) PGBD-C1 (PDZ) MOLECULAR BASIS OF CELL AND DEVELOPMENTAL BIOLOGY |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Biochemistry Molecular Biology |
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