Please wait, while we are loading the content...
Please wait, while we are loading the content...
Content Provider | IET Digital Library |
---|---|
Author | Taghavi, Mahdieh Sadat Akbarzadeh, Azim Mahdian, Reza |
Abstract | Brain tumours develop resistance to chemotherapy mainly due to the presence of the blood brain barrier which partially blocks the penetration of drugs into the brain. Poly(butyl cyanoacrylate) nanoparticles have been extensively proposed for delivering drugs into the brain and have shown their ability to cross the blood brain barrier in vitro and in vivo. However, the application of nanoparticles could be limited by their potential side effects. In this study, two glioblastoma cell lines with the poly(butyl cyanoacrylate) nanoparticles were treated at different concentrations. Through MTT assay, the viability of treated cells was quantified. Induction of apoptosis was analysed by flowcytometry as well as quantitative PCR assay for the expression of BCL2 family genes. The results of this study showed that the treatment with poly(butyl cyanoacrylate) nanoparticles induced neither apoptosis nor necrosis in these cells. The quantitative real-time PCR results showed that poly(butyl cyanoacrylate) nanoparticles treatment caused significant changes in the expression of some BCL2 family members. In conclusion, it seems that poly(butyl cyanoacrylate) nanoparticles treatment at non-toxic dose can change the expression of some apoptosis-related genes in glioblastoma cells while has no significant effect on their viability. |
Starting Page | 1102 |
Ending Page | 1106 |
Page Count | 5 |
Volume Number | 14 |
e-ISSN | 17500443 |
Issue Number | Issue 10, Sep (2019) |
Alternate Webpage(s) | https://digital-library.theiet.org/content/journals/mnl/14/10 |
Alternate Webpage(s) | https://digital-library.theiet.org/content/journals/10.1049/mnl.2019.0034 |
Journal | Micro & Nano Letters |
Publisher Date | 2019-09-04 |
Access Restriction | Open |
Rights Holder | © The Institution of Engineering and Technology |
Subject Keyword | BCL2 Family Genes BCL2 Family Members Biochemistry Biomedical Material Blood Blood Brain Barrier Brain Brain Tumours Cancer Cellular Biophysics Drugs Genetics Glioblastoma Cell Glioblastoma Cell Line Method of Nanofabrication And Processing Molecular Biophysics Nanomedicine Nanoparticle Nanotechnology Application in Biomedicine Patient Care And Treatment Patient Diagnostic Method And Instrumentation Patient Treatment Physical Chemistry of Biomolecular Solutions And Condensed State Physics of Subcellular Structure Poly(butyl Cyanoacrylate) NanoParticle Treatment Toxicology Tumours |
Content Type | Text |
Resource Type | Article |
National Digital Library of India (NDLI) is a virtual repository of learning resources which is not just a repository with search/browse facilities but provides a host of services for the learner community. It is sponsored and mentored by Ministry of Education, Government of India, through its National Mission on Education through Information and Communication Technology (NMEICT). Filtered and federated searching is employed to facilitate focused searching so that learners can find the right resource with least effort and in minimum time. NDLI provides user group-specific services such as Examination Preparatory for School and College students and job aspirants. Services for Researchers and general learners are also provided. NDLI is designed to hold content of any language and provides interface support for 10 most widely used Indian languages. It is built to provide support for all academic levels including researchers and life-long learners, all disciplines, all popular forms of access devices and differently-abled learners. It is designed to enable people to learn and prepare from best practices from all over the world and to facilitate researchers to perform inter-linked exploration from multiple sources. It is developed, operated and maintained from Indian Institute of Technology Kharagpur.
Learn more about this project from here.
NDLI is a conglomeration of freely available or institutionally contributed or donated or publisher managed contents. Almost all these contents are hosted and accessed from respective sources. The responsibility for authenticity, relevance, completeness, accuracy, reliability and suitability of these contents rests with the respective organization and NDLI has no responsibility or liability for these. Every effort is made to keep the NDLI portal up and running smoothly unless there are some unavoidable technical issues.
Ministry of Education, through its National Mission on Education through Information and Communication Technology (NMEICT), has sponsored and funded the National Digital Library of India (NDLI) project.
Sl. | Authority | Responsibilities | Communication Details |
---|---|---|---|
1 | Ministry of Education (GoI), Department of Higher Education |
Sanctioning Authority | https://www.education.gov.in/ict-initiatives |
2 | Indian Institute of Technology Kharagpur | Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project | https://www.iitkgp.ac.in |
3 | National Digital Library of India Office, Indian Institute of Technology Kharagpur | The administrative and infrastructural headquarters of the project | Dr. B. Sutradhar bsutra@ndl.gov.in |
4 | Project PI / Joint PI | Principal Investigator and Joint Principal Investigators of the project |
Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon |
5 | Website/Portal (Helpdesk) | Queries regarding NDLI and its services | support@ndl.gov.in |
6 | Contents and Copyright Issues | Queries related to content curation and copyright issues | content@ndl.gov.in |
7 | National Digital Library of India Club (NDLI Club) | Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach | clubsupport@ndl.gov.in |
8 | Digital Preservation Centre (DPC) | Assistance with digitizing and archiving copyright-free printed books | dpc@ndl.gov.in |
9 | IDR Setup or Support | Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops | idr@ndl.gov.in |
Loading...
|