NDLI: Fabrication of folate-phytosterol-carboxymethyl cellulose nanoparticles derived from plant material as carrier of anticancer drug

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The Journal of Engineering

Fabrication of folate-phytosterol-carboxymethyl cellulose nanoparticles derived from plant material as carrier of anticancer drug

Content Provider	IET Digital Library
Author	Elshazly, Ezzat Hamdy Yu, Lizhen Zhang, Yue Wang, Hui Chen, Kuanmin Zhang, Song Ke, Lixia Gong, Renmin
Abstract	In this work, folate-phytosterol-carboxymethyl cellulose nanoparticles (FPCMC NPs) derived from plant material were fabricated and investigated as carrier of hydrophobic anticancer drugs. Firstly, hydrophobic phytosterol was grafted onto the framework of water-soluble carboxymethyl cellulose. Then folate, as tumor-targeting ligand, was coupled to the phytosterol-carboxymethyl cellulose to become self-assembled FPCMC NPs. The physicochemical properties of the fabricated FPCMC NPs were characterized. Doxorubicin (DOX) was selected as model anticancer drug that was entrapped in prepared FPCMC NPs with satisfactory loading content (7%) and loading efficiency (71.2%). The in vitro drug release test showed that the release amount of DOX from drug-loaded FPCMC NPs at pH 5.3 was much higher than that at pH 6.5 or pH 7.4. The research results indicated that the fabricated FPCMC NPs had the potential as nanocarrier of hydrophobic anticancer drugs for further experimental study.
Starting Page	1111
Ending Page	1116
Page Count	6
Volume Number	14
e-ISSN	17500443
Issue Number	Issue 10, Sep (2019)
Alternate Webpage(s)	https://digital-library.theiet.org/content/journals/mnl/14/10
Alternate Webpage(s)	https://digital-library.theiet.org/content/journals/10.1049/mnl.2019.0080
Journal	Micro & Nano Letters
Publisher Date	2019-09-04
Access Restriction	Open
Rights Holder	© The Institution of Engineering and Technology
Subject Keyword	Cancer Cellular Biophysics Doxorubicin Drug Delivery System Drug-loaded FPCMC NP Folate-phytosterol-carboxymethyl Cellulose NanoParticle Hydrophobic Anticancer Drugs Hydrophobic Phytosterol Hydrophobicity In Vitro Drug Release Test Model Anticancer Drug Nanofabrication Nanomedicine Nanoparticle Nanotechnology Application in Biomedicine Patient Care And Treatment PH Plant Material Self-assembly Self-assembly in Nanofabrication Solubility Tumours Water-soluble Carboxymethyl Cellulose
Content Type	Text
Resource Type	Article

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