NDLI: Brain targeted delivery of anticancer drugs: prospective approach using solid lipid nanoparticles

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Brain targeted delivery of anticancer drugs: prospective approach using solid lipid nanoparticles

Content Provider	IET Digital Library
Author	Anand, Anupriya Sugumaran, Abimanyu Narayanasamy, Damodharan
Abstract	A brain tumour is amongst most devastating and challenging condition to overcome with suitable treatment as the drug has to cross the blood–brain barrier (BBB) with several physiological barriers like opsonisation by the reticuloendothelial system. Presently various techniques such as surgical, chemotherapeutic agents, and radiotherapy techniques have performed to extend the lifespan of patients diagnosed with glioblastoma, which did not maximise the overall survival of patients with a tumour. Nanotechnology is relied upon to diminish the requirement for intrusive methods for conveyance of therapeutics to the central nervous system. Colloidal nanocarriers sizing range 1–1000 nm have been utilised to cross BBB delivers the drug at cell levels with enhanced bioavailability and reduced toxicity. However, solid lipid nanoparticles (SLNs) are considered a highly flexible carrier for more successful remedially in brain tumour. The treatment of a brain tumour via SLNs is gaining greater potency due to its inimitable size and lipidic nature. This review focuses and represents the current strategies of SLNs in the brain tumour treatment with appropriate techniques adopted are highlighted. Based on this review, the authors concluded that SLNs embrace exclusive promising lipidic nanocarrier that could be utilised to target a brain tumour effectively.
Starting Page	353
Ending Page	362
Page Count	10
ISSN	17518741
Volume Number	13
e-ISSN	1751875X
Issue Number	Issue 4, Jun (2019)
Alternate Webpage(s)	https://digital-library.theiet.org/content/journals/iet-nbt/13/4
Alternate Webpage(s)	https://digital-library.theiet.org/content/journals/10.1049/iet-nbt.2018.5322
Journal	IET Nanobiotechnology
Publisher Date	2019-01-28
Access Restriction	Open
Rights Holder	© The Institution of Engineering and Technology
Subject Keyword	Anticancer Drugs BBB Biomedical Material Biophysics of Neurophysiological Processes Blood Blood–brain Barrier Brain Brain Targeted Delivery Brain Tumour Therapeutical Uses Brain Tumour Treatment Cancer Cellular Biophysics Central Nervous System Chemotherapeutic Agents Colloidal Nanocarriers Sizing Range 1–1000 Nm Colloids Drug Drug Delivery System Drugs Lipidic Nanocarrier Lipidic Nature Molecular Biophysics Nanofabrication Nanomedicine Nanoparticle Nanotechnology Application in Biomedicine Neurophysiology Patient Care And Treatment Physiological Barriers Prospective Approach Radiation Therapy Radiotherapy Technique Reticuloendothelial System Size 1.0 Nm to 1000.0 Nm Solid Lipid NanoParticle Surgical Agent Tumours
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology Electronic, Optical and Magnetic Materials Electrical and Electronic Engineering Biotechnology

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