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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Byung-Sam Kim |
| Copyright Year | 2012 |
| Description | Author affiliation: Department of Biological Sciences, University of Ulsan, Ulsan Korea (Byung-Sam Kim) |
| Abstract | Tumor-infiltrating lymphocytes (TILs) play critical roles in host anti-tumor immune responses. It is known that cancer patients with tumor-reactive lymphocyte infiltration in their tumors have better prognoses, while patients with tumors infiltrated by immunosuppressive cells have worse prognoses. We found that administration of 6-gingerol, which is a component of ginger, inhibited tumor growth in several types of murine tumors, such as B16F1 melanomas, Renca renal cell carcinomas and CT26 colon carcinomas, established by inoculating tumor cells on the flanks of mice, although it did not lead to complete eradication of the tumors. 6-gingerol treatment of tumor-bearing mice caused massive infiltration of CD4 and CD8 T-cells and $B220^{+}$ B-cells, but reduced the number of $CD4^{+}Foxp3^{+}$ regulatory T-cells. The CD8 tumor-infiltrating T lymphocytes in 6-gingerol-treated mice strongly expressed IFN-γ, a marker of activation of CTL CD107a cells, and chemokine receptors that are expressed on TH1 cells, such as CXCR3 and CCR5. To test whether 6-gingerol could promote infiltration of tumor antigen-specific CD8 T-cells into tumors, we adoptively transferred CFSE-labeled OT-1 CD8 T-cells into EG7 tumor-bearing mice. We found that CD8 T cells isolated from 6-gingerol pre-treated OT-1 mice, but not from control OT-1 mice, infiltrated massively into tumors and tumor draining lymph nodes and divided several times. Our results strongly suggest that 6-gingerol can be used in tumor immunotherapy to increase the number of TILs. |
| Starting Page | 1 |
| Ending Page | 6 |
| File Size | 538634 |
| Page Count | 6 |
| File Format | |
| ISBN | 9781467317726 |
| e-ISBN | 9781467317733 |
| DOI | 10.1109/IFOST.2012.6357824 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2012-09-18 |
| Publisher Place | Russia |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | gingerol Ethanol tumor infiltrating lymphocytes Mice cancer Colon immunity Tumors Immune system Cancer |
| Content Type | Text |
| Resource Type | Article |
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