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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Hong Rae Cho Byungsuk Kwon |
| Copyright Year | 2012 |
| Description | Author affiliation: Department of Surgery, Ulsan University Hospital, University of Ulsan, Ulsan Korea (Hong Rae Cho) || Department of Biological Sciences, University of Ulsan, Ulsan Korea (Byungsuk Kwon) |
| Abstract | IL-33 is known to play an important role in Th2 immunity. In this study, we investigated the effect of IL-33 pretreatment on anti-fungal response using an acute Candida albicans peritoneal infection model. IL-33 pre-treatment induced a rapid fungal clearance and markedly reduced the C. albicans infection-associated mortality. The priming effect of IL-33 occurred during the recruitment of neutrophils into site of infection. The anti-fungal effect occurred due to the rapid and massive recruitment of neutrophils to the site of infection as a result of the release of CXCR2 chemokines by peritoneal macrophages and by reversal of the TLR-induced reduction of CXCR2 expression in neutrophils during IL-33 priming. Taken together, our results suggest that IL-33 can regulate the anti-fungal activity of neutrophils by collaborative modulation of the signaling pathways of different classes of innate immune receptors. |
| Starting Page | 1 |
| Ending Page | 5 |
| File Size | 1567984 |
| Page Count | 5 |
| File Format | |
| ISBN | 9781467317726 |
| e-ISBN | 9781467317733 |
| DOI | 10.1109/IFOST.2012.6357820 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2012-09-18 |
| Publisher Place | Russia |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Candia albicans Anti-fungal Production Mice Cavity resonators DEctin-1 TLR IL-33 Blood Immune system Recruitment |
| Content Type | Text |
| Resource Type | Article |
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