NDLI: Nanostructure of the "protein-nanoparticle corona" an indicator of toxicity?

Content Provider	IEEE Xplore Digital Library
Author	White, J.W. Lin, J. Ang, J.C. Campbell, R.A. Laux, V. Haertlein, M. Fragneto, G.
Copyright Year	2010
Description	Author affiliation: Research School of Chemistry, Australian National University, Canberra ACT 0200, Australia (White, J.W.; Lin, J.; Ang, J.C.) \|\| Institut Laue-Langevin, 6, rue Jules Horowitz, BP 156 - 38042 Grenoble, Cedex 9, France (Campbell, R.A.; Laux, V.; Haertlein, M.; Fragneto, G.)
Abstract	Nanoparticle-protein complexes comprising silica or cadmium sulfide nanoparticles with human proteins have been detected with high sensitivity at the air-water interface using X-ray and neutron reflectivity measurements and ellipsometry. For the interaction between β-casein and 8 nm silica particles the sensitivity of the reflectivity signal at the air-water interface has been shown by X-ray reflectmetry to be pico-molar. This high sensitivity results from the nanoparticle-protein interaction which generates surface active complexes. The interaction between human serum albumin and cadmium sulfide nanoparticles has been detected using neutron reflectometry and tracked kinetically by ellipsometry. Here we have shown that lateral domains or aggregates in the surface monolayer change in size or dissipate over the course of several hours. The three methods of monitoring the protein-nanoparticle interaction during film evolution are discussed.
Starting Page	289
Ending Page	292
File Size	1665650
Page Count	4
File Format	PDF
ISBN	9781424452613
DOI	10.1109/ICONN.2010.6045250
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2010-02-22
Publisher Place	Australia
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	toxicity Cadmium Films Humans Neutrons nanoparticle reflectivity Nanoparticles Proteins Reflectivity protein sensitivity X-ray corona
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in