NDLI: The loading and release property of nanoporous anodic alumina for delivery of drugs and drug carriers

Content Provider	IEEE Xplore Digital Library
Author	Moom Sinn Aw Simovic, S. Dhiraj, K. Addai-Mensah, J. Losic, D.
Copyright Year	2010
Description	Author affiliation: Ian Wark Research Institute, the University of South Australia, Mawson Lakes Campus, Mawson Lakes Boulevard, Mawson Lakes, SA 5095 Australia (Moom Sinn Aw; Simovic, S.; Dhiraj, K.; Addai-Mensah, J.; Losic, D.)
Abstract	A two-step electrochemical anodisation approach was adopted in this work to create a series of highly ordered mesopores etched with different diameter (60 to 160 nm) and uniform nanotube length in anodised aluminium oxide (AAO). The loading and release characteristics of model drug (indomethacin) and drug carriers (micelles named Pluronic F127, TPGS, PEO-PPO-PEO) were presented to investigate the influence of micelle size, pore diameter and surface modification of AAO on release studies. Surface chemistry was varied via silanation process, using AFTES and PFPTES. It was discovered that quicker release of drugs was induced by larger pore size and smaller micelles. Moreover drug release was found to favour hydrophobic surface as the release was faster in PFPTES modified AAO than the one with APTES.
Starting Page	143
Ending Page	145
File Size	261622
Page Count	3
File Format	PDF
ISBN	9781424452613
DOI	10.1109/ICONN.2010.6045213
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2010-02-22
Publisher Place	Australia
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Drugs polymeric micelle Scanning electron microscopy Chemistry Loading Drug delivery drug delivery Polymers Surface treatment drug carrier anodic alumina
Content Type	Text
Resource Type	Article

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