NDLI: The Investigation of Dynamically Immobilized MAO on JAM Using Biologically Functionalized Chromatography

Content Provider	IEEE Xplore Digital Library
Author	Yueying Liu Rongji Dai Feng Qu Weiwei Meng Yulin Deng
Copyright Year	2007
Description	Author affiliation: Beijing Inst. of Technol., Beijing (Yueying Liu; Rongji Dai; Feng Qu; Weiwei Meng; Yulin Deng)
Abstract	In this paper, the retention times of serotonin (5-HT) were investigated on IAM (immobilized artificial membrane) column and IAM-MAO column which MAO was inhibited by clorgyline at various concentrations. The retention time of 5-HT on IAM column was shorter than that on IAM-MAO column. With the increasing of inhibitor concentrations, the retention time of 5-HT on IAM-MAO column became shorter and shorter. The results demonstrated that the MAO was successfully immobilized on IAM. The dynamical immobilized MAO retained its bioactivity. The establishment of artificial cell could better simulate the interaction between 5-HT and MAO in organism. Thus this study proved that BioFC (biologically functionalized chromatography) might become a new concept and method to simulate cell (artificial cell) and a possible tool for the drug screening in the future.
Starting Page	1787
Ending Page	1791
File Size	956773
Page Count	5
File Format	PDF
ISBN	9781424410774
DOI	10.1109/ICCME.2007.4382055
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2007-05-23
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Biological system modeling Humans Biology Organisms Proteins Inhibitors dynamical immobilization Biological processes Cells (biology) Biomembranes MAO 5-HT Positron emission tomography clorgyline
Content Type	Text
Resource Type	Article

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