NDLI: Comparison of Stability for All-trans Retinoic Acid Nanosuspensions and Lipid Nanoparticle Formulations

Content Provider	IEEE Xplore Digital Library
Author	Ma, Q.H. Tong, S. Duan, L. Xia, Q. Gu, N.
Copyright Year	2007
Description	Author affiliation: Southeast Univ., Nanjing (Ma, Q.H.; Tong, S.)
Abstract	The principal aim of this study was to compare the stability of different nanoparticle formulations with lipophilic and chemically unstable model drug nW-trans retinoic acid (ATRA). ATRA nanoparticles (ATRA-NP) and ATRA-loaded solid lipid nanoparticles (ATRA-SLN, palmitic acid as solid lipid matrix) were prepared by solvent injection method, whilst ATRA-loaded nanostructured lipid carriers (ATRA-NLC, glyceryl monostearate and palmitic acid (3:1 w/w) as solid lipid matrix, soybean oil as liquid lipid material), ATRA-SLN (glyceryl monostearate as solid lipid matrix), and ATRA-loaded nanoemulsions (ATRA-NE, soybean oil as liquid lipid material) were successfully prepared by melt high pressure homogenization method. The chemical stability of ATRA was determined by HPLC analysis. It was found that ATRA in all tested colloidal carriers was more stable than that in methanol solution. The type of colloidal carries systems, preparation method, lipid phase state, concentration of lipid and drug had a strong influence on the chemical stability of ATRA. ATRA was more stable in SLN than in NP, which were both produced by solvent injection method. However, ATRA-NP produced by solvent injection method showed higher stability than ATRA-SLN produced by melt high pressure homogenization method. Additionally, ATRA was more stable when it was incorporated in SLN than that entrapped in NLC or NE. The concentration of lipid or drug also influenced the stability of ATRA. We conclude that ATRA-NP or ATRA-loaded lipid nanoparticle formulations can satisfy the needs for improving both the solubility and stability limitations of ATRA.
Starting Page	197
Ending Page	202
File Size	2077069
Page Count	6
File Format	PDF
ISBN	9781424410774
DOI	10.1109/ICCME.2007.4381721
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2007-05-23
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Drugs Solvents Chemical analysis Stability Nanoemulsion Lipidomics Stability analysis Nanosuspension Petroleum Nanoparticles Nanostructured lipid carriers All-trans retinoic acid Solids Nanostructured materials Solid lipid nanoparticles Testing
Content Type	Text
Resource Type	Article

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