NDLI: Inter-Frame Co-Registration of Dynamically Acquired Fluoro-Deoxyglucose Positron Emission Tomography Human Brain Data

Content Provider	IEEE Xplore Digital Library
Author	Chen, K. Smilovici, O. Lee, W. Reschke, C. Zhu, Z. Bandy, D. Reiman, E.
Copyright Year	2007
Description	Author affiliation: Banner Alzheimer Inst. & Banner Good Samaritan Positron Emission Tomography Center, Phoenix (Chen, K.; Smilovici, O.; Lee, W.; Reschke, C.)
Abstract	When acquiring positron emission tomography (PET) brain scans dynamically from a patient, it would be helpful to be able to minimize confounding effects of his/her head movement. In this study, we attempted to coregister sequential frames in the dynamic fluorodeoxyglucose (FDG) PET image sequence, specifically addressing the challenge associated with the relatively low radiotracer uptake over the cortical areas in the early short frames. PET data were acquired dynamically over sixty minutes in three healthy volunteers (frame durations ranged from 2 seconds to 5 minutes). We realigned each of the early short frames to its immediate predecessor using normalized mutual information (NMI). Afterward, the same procedure was repeated to realign the summation of the early frames, as well as each of the later frames with durations of 5 minutes and sufficient cortical tracer uptake. To validate our proposed procedure, we artificially moved frames using known linear rotations and translocations and compared the 6 NMI estimated rigid-body transformation parameters to the actual misalignment parameters and compared image-derived carotid artery FDG input function in the realigned and original images. While counting statistics in the first 3 frames (22 seconds after FDG administration) precluded us from accurately addressing misalignments, the NMI reliably recovered translocations as great as 7 mm and rotations as great as 8 degrees for all other frames. Moreover, misalignment errors in the constructed input function from the carotid artery region were able to be corrected. Our NMI-based strategy for the realignment of sequential frames appears to provide a helpful way to determine the severity of the head movement during a PET scan and correct for the effects. Additional studies are needed to address additional confounds associated with the misalignment between transmission and emission scans.
Starting Page	901
Ending Page	906
File Size	3494410
Page Count	6
File Format	PDF
ISBN	9781424410774
DOI	10.1109/ICCME.2007.4381871
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2007-05-23
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Head USA Councils Magnetic resonance imaging Humans Attenuation Mathematics Positron emission tomography Alzheimer's disease Statistics Biomedical imaging
Content Type	Text
Resource Type	Article

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