NDLI: Brain circuit model for drug addiction

Content Provider	IEEE Xplore Digital Library
Author	Hani, A.F.M. Haq, N.U. Kumar, D. Wei, E.H.T.
Copyright Year	2014
Description	Author affiliation: Centre for Intell. Signal & Imaging Res., Univ. Teknol. PETRONAS, Tronoh, Malaysia (Hani, A.F.M.; Haq, N.U.; Kumar, D.; Wei, E.H.T.)
Abstract	Drug addiction is one of the chronic mental disorders that results in a compulsive behavior to seek and consume drug. Recent statistics show that about 15% of world population is addicted with some sort of drug. It has been reported that drug addiction causes structural such as change in volume of gray and/or white matter, and functional neuroplasticity such as changes in the concentration of neurotransmitter (dopamine, glutamate, GABA etc.). Functional neuroplasticity can either block or excite neurotransmission among the neurons, hence altering the functionality of neurons and disrupt the control mechanism in the reward pathway and finally leading to an uncontrolled behavior. In drug addiction, the occurrence of uncontrolled behaviors in the different regions of reward pathways can be modeled using brain circuit to map directly the neural activities. This paper discusses the biological & chemical processes and control mechanisms involved in drug addiction develops a model of brain circuit under the influence of drug. It is observed that reduced inhibitory neurotransmission of GABA and increased excitatory neurotransmission of Glutamate in different regions of brain circuit contributes to reorganization of control mechanism by impaired encoding in control regions (PFC and Cigulate Gyrus). As a result, the drug related reward is considered as reinforcement of drug taking. Furthermore, it is also argued that estimation and quantification of GABA and Glutamate may provide significant differences between normal and drug addict brain that will lead to development of drug addiction severity monitoring system.
Sponsorship	Malaysia Sect. CAS Chapt.
Starting Page	1
Ending Page	5
File Size	1115852
Page Count	5
File Format	PDF
e-ISBN	9781479946532
DOI	10.1109/ICIAS.2014.6869524
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2014-06-03
Publisher Place	Malaysia
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Drugs Nerve fibers Neurotransmitters Animals Biomedical monitoring Monitoring
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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