NDLI: Composite Contrast Approach for Cellular MRI using the Combination of Gadolinium Chelates and Iron Oxide Particles

Content Provider	IEEE Xplore Digital Library
Author	Young Beom Kim HyunWook Park Seung-Schik Yoo
Copyright Year	2007
Description	Author affiliation: Korea Adv. Inst. of Sci. & Technol., Daejeon (Young Beom Kim; HyunWook Park; Seung-Schik Yoo)
Abstract	There are growing interests of molecular and cellular imaging. A number of imaging modalities have been developed for acquiring biological information. Magnetic resonance imaging (MRI) is an excellent method for observing brain function and bio/molecular information with noninvasive and in-vivo state and for excellent anatomical resolution. Contrast agent gives plentiful ability to MR imaging through signal enhancement and functional detection. Gadolinium chelates and superparamagnetic iron oxide particles (SPIOs) are widely used MR contrast agents that have different relaxation properties of positive and negative contrasts respectively. We suggested a method exhibiting both contrast characteristics by using two contrast agents with aqueous mixture. We performed MR imaging for measuring the relaxation effects of composite samples and demonstrated the attainable dual-contrast characteristics within appropriate concentration. The method may overcome the present limitation of cellular MRI using SPIO and be applied to cell labeling with tuneable contrast for cell therapy and regenerative medicine.
Starting Page	157
Ending Page	162
File Size	2696251
Page Count	6
File Format	PDF
ISBN	1424412196
DOI	10.1109/ICIA.2007.4295717
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2007-07-08
Publisher Place	South Korea
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Visualization Optical imaging Iron superparamagnetic Nanoparticles Magnetic resonance imaging Paramagnetic materials composite contrast MRI contrast agent paramagnetic Labeling Positron emission tomography Medical diagnostic imaging Biomedical imaging relaxation property
Content Type	Text
Resource Type	Article

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