NDLI: Increased transverse relaxivity in ultrasmall superparamagnetic iron oxide nanoparticles used as MRI contrast agent for biomedical imaging.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Mishra, Sushanta Kumar Kumar, B. S. Hemanth Khushu, Subash Tripathi, Rajendra P. Gangenahalli, Gurudutta
Description	Country affiliation: India Author Affiliation: Mishra SK ( NMR Research Centre, Institute of Nuclear Medicine and Allied Sciences (INMAS), DRDO, New Delhi, India.); Kumar BS ( Division of Stem Cells and Gene Therapy Research, Institute of Nuclear Medicine and Allied Sciences (INMAS), DRDO, New Delhi, India.); Khushu S ( NMR Research Centre, Institute of Nuclear Medicine and Allied Sciences (INMAS), DRDO, New Delhi, India.); Tripathi RP ( NMR Research Centre, Institute of Nuclear Medicine and Allied Sciences (INMAS), DRDO, New Delhi, India. skhushu@yahoo.com.); Gangenahalli G ( NMR Research Centre, Institute of Nuclear Medicine and Allied Sciences (INMAS), DRDO, New Delhi, India.)
Abstract	Synthesis of a contrast agent for biomedical imaging is of great interest where magnetic nanoparticles are concerned, because of the strong influence of particle size on transverse relaxivity. In the present study, biocompatible magnetic iron oxide nanoparticles were synthesized by co-precipitation of Fe and Fe salts, followed by surface adsorption with reduced dextran. The synthesized nanoparticles were spherical in shape, and 12 ± 2 nm in size as measured using transmission electron microscopy; this was corroborated with results from X-ray diffraction and dynamic light scattering studies. The nanoparticles exhibited superparamagnetic behavior, superior T relaxation rate and high relaxivities (r = 18.4 ± 0.3, r = 90.5 ± 0.8 s mM , at 7 T). MR image analysis of animals before and after magnetic nanoparticle administration revealed that the signal intensity of tumor imaging, specific organ imaging and whole body imaging can be clearly distinguished, due to the strong relaxation properties of these nanoparticles. Very low concentrations (3.0 mg Fe/kg body weight) of iron oxides are sufficient for early detection of tumors, and also have a clear distinction in pre- and post-enhancement of contrast in organs and body imaging. Many investigators have demonstrated high relaxivities of magnetic nanoparticles at superparamagnetic iron oxide level above 50 nm, but this investigation presents a satisfactory, ultrasmall, superparamagnetic and high transverse relaxivity negative contrast agent for diagnosis in pre-clinical studies. Copyright © 2016 John Wiley & Sons, Ltd.
File Format	HTM / HTML
ISSN	15554309
Issue Number	5
Journal	Contrast Media & Molecular Imaging
Volume Number	11
e-ISSN	15554317
Language	English
Publisher	Wiley
Publisher Date	2016-09-01
Publisher Place	United States
Access Restriction	Subscribed
Subject Keyword	Discipline Diagnostic Imaging
Content Type	Text
Resource Type	Article
Subject	Radiology, Nuclear Medicine and Imaging

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