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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Arndt, W. Asbury, T.M. Zheng, W.J. Mitman, M. Jijun Tang |
| Copyright Year | 2011 |
| Description | Author affiliation: Bioinformatics Division, Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC (Arndt, W.; Asbury, T.M.; Zheng, W.J.) || Department of Computer Science Engineering, University of South Carolina, Columbia, SC (Mitman, M.; Jijun Tang) |
| Abstract | New technologies permit the measurement of many types of genomic and epigenomic information at scales ranging from the atomic to nuclear. Much of this new data is structural in nature and challenging to coordinate with existing data formats. There is an increasing need to integrate and visualize disparate data sets in order to reveal structural relationships not apparent when viewing these data formats separately. We have developed the Genome3D software package in order to integrate and display epigenomic data within the context of a three-dimensional physical model of the human genome. To our knowledge, this is the first such tool developed to visualize human genome in three dimensions. Here we describe the major features of Genome3D and discuss our multi-scale data framework using a representative basic physical model. Additionally, utilities to generate demonstration models of common chromosome interaction scenarios derived from High-C or CHIA-PET analysis are under development. These models are compatible with existing annotation data formats and can demonstrate common situations where one or more chromosomes are arranged such that two or more interaction sites appear in close proximity. These models can be used to directly create publication images without resorting to intermediate use of image editing software. Availability: http://genomebioinfo.musc.edu/Genome3D/Index.html |
| Starting Page | 936 |
| Ending Page | 938 |
| File Size | 755511 |
| Page Count | 3 |
| File Format | |
| ISBN | 9781457716126 |
| e-ISBN | 9781457716133 |
| DOI | 10.1109/BIBMW.2011.6112510 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2011-11-12 |
| Publisher Place | USA |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Genomics DNA Data visualization Data models Three dimensional displays Bioinformatics Biological cells |
| Content Type | Text |
| Resource Type | Article |
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