NDLI: Learning from positive and unlabeled documents for automated detection of alternative splicing sentences in medline abstracts

Content Provider	IEEE Xplore Digital Library
Author	Yang Chen Torii, M. Chang-Tien Lu Hongfang Liu
Copyright Year	2011
Description	Author affiliation: College of Medicine, Mayo Clinic Rochester, MN, USA (Hongfang Liu) \|\| Dept. of Computer Science, Virginia Tech Falls Church, VA, USA (Chang-Tien Lu) \|\| School of Medicine, Georgetown University, Washington, DC, USA (Torii, M.) \|\| Dept. of Computer Science, Virginia Tech, Falls Church, VA, USA (Yang Chen)
Abstract	Alternative splicing is considered to be a key factor underlying increased cellular and functional complexity in higher eukaryotes. With the advance of high-throughput genomics technologies, it becomes critical to mine alternative splicing knowledge from biological research literature. Meanwhile, there have been many papers published on DNA splicing and translation and it is time-consuming to find papers specifically relevant to alternative splicing. Observing that documents reporting alternative splicing can be obtained from existing knowledge bases recording literature evidences and also that a large number of unlabeled documents are freely available, we investigated learning from positive and unlabeled data (LPU) for retrieving papers relevant to alternative splicing. The positive documents are from Literature Support for Alternative Transcripts (LSAT) and unlabeled documents are obtained from Gene Reference Into Function (GeneRIF). We generated nine unlabeled datasets different in size or the way documents were sampled, and compared the performance of document classifiers built using different unlabeled datasets and machine learning algorithms. The study shows that LPU is a viable strategy to build document filtering system, while the performance of trained classifiers is affected by the choice of the unlabeled data set. Selection of machine learning algorithms and that of unlabeled documents would be critical in constructing an effective LPU-based system.
Starting Page	530
Ending Page	537
File Size	877571
Page Count	8
File Format	PDF
ISBN	9781457716126
e-ISBN	9781457716133
DOI	10.1109/BIBMW.2011.6112425
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2011-11-12
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Support vector machines Training LPU Machine learning algorithms Splicing Alternative Splicing Classification algorithms Reliability Data mining Document Retrieval
Content Type	Text
Resource Type	Article

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