NDLI: Systematic discovery of condition specific Wnt signaling subnetworks

Content Provider	IEEE Xplore Digital Library
Author	Saha, S. Ewing, R.M.
Copyright Year	2011
Description	Author affiliation: Center for Proteomics and Bioinformatics, Case Western Reserve University, Cleveland, USA (Saha, S.; Ewing, R.M.)
Abstract	Wnt signaling is a critically important signaling pathway in development, differentiation and embryogenesis and is broadly conserved amongst multicellular animals. Dis-regulation of Wnt signaling is associated with many human cancers, in particular colorectal cancer. Multiple branches of the Wnt signaling pathway (‘canonical’ and ‘non-canonical’) have been defined, although increasingly these are viewed as a single interconnected signaling network. A principal challenge in Wnt signaling research is to understand the connectivity between different branches, and to understand how different branches of Wnt signaling function in different biological states. To better understand this complex network, we analyze Wnt signaling in the context of diverse cell-lines, tissues and adenomas. By integrating gene-expression datasets representing these different biological states with interaction networks, we identify Wnt subnetworks activated in different biological states. We identified 10 active subnetworks in the network of 2072 protein-protein interactions from a Wnt-focused interaction network. These subnetworks were used for classification of samples and we show that classification of these samples using subnetworks rather than gene-expression profiles alone identifies potentially significant commonalities between samples. Specifically, we identify a subnetwork common to lung and colon adenoma samples, reflecting the common origin of these tumors. The approach described here will be used in future for integration of diverse Wnt-focused ‘omics’ datasets, for both defining components of the signaling network itself, as well as to reveal commonalities and distinctions between Wnt signaling under different biological states.
Starting Page	229
Ending Page	234
File Size	870113
Page Count	6
File Format	PDF
ISBN	9781457716126
e-ISBN	9781457716133
DOI	10.1109/BIBMW.2011.6112379
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2011-11-12
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	interaction network Conferences subnetwork Wnt signaling network Bioinformatics
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Condition specific subnetwork identification using an optimization model (2008).

Deriving behavior of boolean bioregulatory networks from subnetwork dynamics

Microarray vs. RNA-Seq: a comparison for active subnetwork discovery

Automatic context-specific subnetwork discovery from large interaction networks

Automatic Context-Specific Subnetwork Discovery from Large Interaction Networks

Modularity in neural computing (1999)

Systematic drug repositioning: A new paradigm in drug discovery

Relations between the dynamics of network systems and their subnetworks

Automatic Context-Specific Subnetwork Discovery from Large Interaction Networks

Systematic discovery of condition specific Wnt signaling subnetworks

Similar Documents

Condition specific subnetwork identification using an optimization model (2008).

Deriving behavior of boolean bioregulatory networks from subnetwork dynamics

Microarray vs. RNA-Seq: a comparison for active subnetwork discovery

Automatic context-specific subnetwork discovery from large interaction networks

Automatic Context-Specific Subnetwork Discovery from Large Interaction Networks

Modularity in neural computing (1999)

Systematic drug repositioning: A new paradigm in drug discovery

Relations between the dynamics of network systems and their subnetworks

Automatic Context-Specific Subnetwork Discovery from Large Interaction Networks

Systematic discovery of condition specific Wnt signaling subnetworks