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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Rashid, S. Maruf, G.M. |
| Copyright Year | 2011 |
| Description | Author affiliation: Dept. of ECE, University of British Columbia, Vancouver, Canada (Rashid, S.) || Dept. of CSE, United International University, Dhaka, Bangladesh (Maruf, G.M.) |
| Abstract | A significant challenge in DNA microarray and mass spectrometric data analysis can be attributed to the problem of having a large number of features with a small number of samples or patients in the data set. Particular care is required to deal with such a problem as the low classification accuracy of a model brought about by the small number of features may depict a low predictive capability. To overcome the associated challenges, proper approaches for data preprocessing, feature reduction and identifying the optimal set of features are critical. In this paper, a novel technique has been proposed for feature reduction and cancer classification; which is applicable for two different types of biological data. The proposed method has been implemented on Surface enhanced laser desorption/ionization time-of-flight mass spectrometric (SELDI-TOF-MS) and DNA microarray data sets. This technique is self adaptive and independent of the type data sets. We have developed a two step strategy for feature reduction such as (1) data preprocessing which includes merging and t-testing and (2) wavelet decomposition. For classification purpose, support vector machine (SVM) has been proposed. By evaluating the performance of the proposed algorithm on the two types of datasets it has been shown that the classification accuracy, sensitivity and specificity obtained by the features selected by the proposed method consistently give excellent performance. |
| Starting Page | 305 |
| Ending Page | 312 |
| File Size | 1138380 |
| Page Count | 8 |
| File Format | |
| ISBN | 9781457716126 |
| e-ISBN | 9781457716133 |
| DOI | 10.1109/BIBMW.2011.6112391 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2011-11-12 |
| Publisher Place | USA |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Support vector machines Algorithm design and analysis Accuracy microarray support vector machine SELDI-TOF Proteomics t-test wavelet decomposition Kernel Least squares approximation Cancer |
| Content Type | Text |
| Resource Type | Article |
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