NDLI: Coronary atherosclerotic plaque characterization using IVUS elastography and Raman spectroscopy

Content Provider	IEEE Xplore Digital Library
Author	van de Poll, S.W.E. de Korte, C.L. van der Steen, A.F.W. Puppels, G.J. van der Laarse, A.
Copyright Year	2000
Description	Author affiliation: Med. Center, Leiden Univ., Netherlands (van de Poll, S.W.E.)
Abstract	The composition of atherosclerotic lesions is considered to be an important determinant for the development of acute coronary ischemic syndromes. We investigated the potentials of a combination of intravascular ultrasound (IVUS) elastography and intravascular near infrared Raman spectroscopy, to assess the geometry and physical and chemical composition of normal vessel wall and plaque. Intact human coronary arteries were mounted in an in vitro pressurized perfusion setup. At selected cross-sections, two echo-frames were acquired at different intraluminal pressures to obtain elastograms. Subsequently, Raman spectra were acquired in 30 seconds at four different angles using a sideways viewing Raman catheter. Spectra were modeled to extract quantitative chemical information. Calcified areas were identifiable on the echograms, elastograms and Raman spectra. A combination of geometric information provided by the echogram, chemical information as obtained with Raman spectroscopy, and high stress regions determined by the elastogram, may prove to be valuable for identification of vulnerable plaques in vivo.
Starting Page	1775
Ending Page	1778
File Size	373586
Page Count	4
File Format	PDF
ISBN	0780363655
ISSN	10510117
DOI	10.1109/ULTSYM.2000.921666
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2000-10-22
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Chemicals Raman scattering Spectroscopy Lesions Ultrasonic imaging Infrared spectra Geometry Humans Arteries In vitro
Content Type	Text
Resource Type	Article

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