NDLI: Ultrasound contrast agent behavior near the fragmentation threshold

Content Provider	IEEE Xplore Digital Library
Author	Wen-Shiang Chen Matula, T.J. Crum, L.A.
Copyright Year	2000
Description	Author affiliation: Appl. Phys. Lab., Washington Univ., Seattle, WA, USA (Wen-Shiang Chen)
Abstract	Understanding the fragmentation process of ultrasound contrast agents is important in therapeutic ultrasound applications (such as ultrasound-enhanced drug delivery), as well as in certain imaging applications (such as "flash echo" imaging. In the fragmentation of Optison/sup TM/ microbubbles, our observations suggest that there are two pressure thresholds, a threshold which leads to shell rupture and the production of smaller daughter bubbles, and another one leading to the onset of sustained inertial cavitation activity. Between the shell-disruption threshold and sustained IC threshold is a region where intermittent inertial cavitation activity was detected. The acoustic signature of the intermittent region, the pressure level for the various thresholds, and the strength of the subsequent cavitation activity are all highly dependent on the acoustic pulse parameters.
Starting Page	1935
Ending Page	1938
File Size	377875
Page Count	4
File Format	PDF
ISBN	0780363655
ISSN	10510117
DOI	10.1109/ULTSYM.2000.921702
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2000-10-22
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Ultrasonic imaging Acoustic pulses Pulse measurements Acoustic scattering Rayleigh scattering Equations Physics Laboratories Drug delivery Production
Content Type	Text
Resource Type	Article

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