NDLI: Evaluation of liquid perfluorocarbon nanoparticles as a blood pool contrast agent utilizing power Doppler harmonic imaging

Content Provider	IEEE Xplore Digital Library
Author	Ngo, F.C. Hall, C.S. Marsh, J.N. Fuhrhop, R.W. Allen, J.S. Brown, P. McLean, M.D. Scott, M.J. Wickline, S.A. Lanza, G.M.
Copyright Year	2000
Description	Author affiliation: Cardiovascular Div., Washington Univ. Sch. of Med., St. Louis, MO, USA (Ngo, F.C.)
Abstract	Improved echocardiographic endocardial border delineation aids in the assessment of ventricular function and wall motion abnormalities. Microbubble-based contrast agents provide excellent echogenicity but a short-lived effect. In contrast, liquid perfluorocarbon (PFC) nanoparticles exhibit long circulatory times and are stable to insonification but have poor echogenicity. Ideally, a contrast agent should demonstrate long circulatory persistence, resistance to ultrasonic destruction, while displaying significant echogenicity. This study demonstrates the effectiveness of biocompatible, liquid PFC nanoparticles as a blood pool contrast agent. When imaged with power Doppler harmonic imaging (PDHI), this agent exhibited marked blood pool enhancement lasting over 1 hour. Furthermore, the contrast enhancement was achieved at doses of 0.7% blood volume. In order to investigate the influence of particle size on blood pool contrast effect, liquid PFC nanoparticles were formulated with diameters of 232 and 465 nm. The nanoparticles were then administered to canines (N=10), with 7 canines receiving the 232 nm nanoparticles and the remainder receiving the 465 nm nanoparticles at a dose of 0.5 ml/kg. PDHI revealed marked blood pool enhancement in all three canines receiving the 465 nm nanoparticles but minimal contrast effect in the canines receiving the 232 nm nanoparticles. This data suggests that PFC nanoparticles in conjunction with PDHI may serve as an important adjunct for the assessment of ventricular function and wall motion abnormalities.
Starting Page	1931
Ending Page	1934
File Size	361963
Page Count	4
File Format	PDF
ISBN	0780363655
ISSN	10510117
DOI	10.1109/ULTSYM.2000.921701
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2000-10-22
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Blood Nanoparticles Ultrasonic imaging Acoustic imaging Power system harmonics Attenuation Acoustic pulses Biomedical imaging Cardiology Lungs
Content Type	Text
Resource Type	Article

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