NDLI: An Inverse Method for Imaging the Local Elasticity of Atherosclerotic Coronary Plaques

Content Provider	IEEE Xplore Digital Library
Author	Baldewsing, R.A. Danilouchkine, M.G. Mastik, F. Schaar, J.A. Serruys, P.W. van der Steen, A.F.W.
Copyright Year	1997
Abstract	The rupture of thin-cap fibroatheroma (TCFA) plaques is a major cause of acute coronary events. A TCFA has a trombogenic soft lipid core, shielded from the blood stream by a thin, possibly inflamed, stiff cap. The majority of atherosclerotic plaques resemble a TCFA in terms of overall structural composition, but have a more complex, heterogeneous morphology. An assessment of the material distribution is vital for quantifying the plaque's mechanical stability and for determining the effect of plaque-stabilizing pharmaceutical agents. We describe a new automated inverse elasticity method, intravascular ultrasound (IVUS) modulography, which is capable of reconstructing a heterogeneous Young's modulus distribution. The elastogram (i.e., spatial strain distribution) of the plaque is the input for the method, and is measured using the clinically available technique, IVUS elastography. Our method incorporates a novel divide-and-conquer strategy, allowing the reconstruction of TCFAs as well as heterogeneous plaques with localized regions of soft, weakened tissue. The method was applied to ex vivo elastograms, which were simulated from the cross sections of postmortem human coronary plaques. To demonstrate the clinical feasibility of the method, measured elastograms from human atherosclerotic coronary arteries were analyzed. One elastogram was measured in vitro; the other, in vivo . The method approximated the true Young's modulus distribution of all simulated plaques, while the in vitro reconstruction was in agreement with histology. In conclusion, the IVUS modulography in combination with the IVUS elastography has strong potential to become an all-encompassing modality for detecting plaques, for assessing the information related to their rupture-proneness, and for imaging their heterogeneous elastic material composition.
Sponsorship	IEEE Engineering in Medicine and Biology Society IEEE Computer Society
Starting Page	277
Ending Page	289
Page Count	13
File Size	1076242
File Format	PDF
ISSN	10897771
Volume Number	12
Issue Number	3
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2008-01-01
Publisher Place	U.S.A.
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Inverse problems Elasticity Image reconstruction Strain measurement Humans In vitro Lipidomics Blood Streaming media Morphology Young's modulus Deformable finite element model human atherosclerotic coronary arteries intravascular ultrasound (IVUS) elastography inverse elasticity problem optimization strain vulnerable plaque Intravascular ultrasound Elastography Vulnerable plaque Human atherosclerotic coronary arteries Inverse elasticity problem Optimization Strain
Content Type	Text
Resource Type	Article
Subject	Electrical and Electronic Engineering Computer Science Applications Biotechnology

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