NDLI: Neural substrates for the retrieval of conditioned taste aversion revealed by manganese-enhanced MRI

Content Provider	IEEE Xplore Digital Library
Author	Inui, T. Shimura, T. Yoshioka, Y. Inui-Yamamoto, C. Ohzawa, I.
Copyright Year	2014
Description	Author affiliation: Lab. of Biofunctional Imaging, Osaka Univ., Suita, Japan (Yoshioka, Y.) \|\| Dept. of Behav. Sci., Osaka Univ., Suita, Japan (Inui, T.; Shimura, T.) \|\| Grad. Sch. of Frontier Biosci., Osaka Univ., Suita, Japan (Ohzawa, I.) \|\| Dept. of Oral Anatomy, Osaka Dental Univ., Hirakata, Japan (Inui-Yamamoto, C.)
Abstract	Memory is an important and dominant function of the brain. However, the neural mechanisms underlying memory function remain unclear. Conditioned taste aversion (CTA) is a useful model for the study of memory, in which a pairing of taste with visceral malaise produces robust aversive memory. Although many studies have investigated the brain regions involved in the acquisition of CTA, the neural mechanisms underlying the retrieval of CTA are a matter of debate. Because several lines of evidence indicate that the amygdala plays a role in CTA, we examined the activation of efferent projections from the basolateral nucleus of the amygdala (BLA) upon the retrieval of CTA memory, by using the manganese-enhanced MRI (MEMRI) technique. The rats presented with conditioned aversive saccharin showed enhanced activities of the neural projections from the BLA to the nucleus accumbens core (NAcC). Therefore, we also investigated whether CTA retrieval activates the output neurons in the NAcC predominantly projecting to the ventral pallidum (VP) by using MEMRI. The conditioned aversive saccharin induced stronger activation of the NAcC-VP projections than the normally preferred saccharin did. The NAcC-VP projections are mainly GABAergic. Further pharmacological and microdialysis studies clarified the involvement of VP GABAergic transmission in the retrieval of CTA memory. Thus, we conclude that the BLA-NAcC-VP pathway is a key component of the neural systems underlying CTA retrieval.
Starting Page	225
Ending Page	229
File Size	1341517
Page Count	5
File Format	PDF
ISBN	9781889335490
DOI	10.1109/WAC.2014.6935794
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2014-08-03
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	TSI Press
Subject Keyword	Manganese ventral pallidum memory conditioned taste aversion manganese-enhanced MRI basolateral nucleus of the amygdala nucleus accumbens
Content Type	Text
Resource Type	Article

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