NDLI: Electrochemical telomerase assay for oral cancer screening

Content Provider	IEEE Xplore Digital Library
Author	Tominaga, K. Hayakawa, M. Sato, S. Kodama, M. Habu, M. Takenaka, S.
Copyright Year	2014
Description	Author affiliation: Dept. of Oral & Maxillofacial Surg., Kyushu Dental Univ., Kitakyushu, Japan (Tominaga, K.; Hayakawa, M.; Kodama, M.; Habu, M.) \|\| Dept. of Appl. Chem., Kyushu Inst. of Technol., Kitakyushu, Japan (Sato, S.; Takenaka, S.)
Abstract	Telomerase has long been known as a cancer marker. As an easy-to-perform oral cancer screening system, we established a new electrochemical telomerase assay (ECTA) method that is superior to a telomerase repeat amplification protocol assay, a popular method for detection of telomerase activity. In the present study, we employed 3 types of clinical samples to examine the sensitivity and specificity of ECTA. Three types of samples were obtained from 44 oral squamous cell carcinoma patients and 16 healthy volunteers; exfoliated cells from the whole oral cavity, exfoliated cells from local lesions, and tissue samples from lesions. Telomerase activity was determined in the samples using ECTA. The increase in current in the oral cancer group was significantly higher than that in the healthy volunteer group for each sample type, while there were no significant differences among the 3 sample types in the oral cancer group. The sensitivity and specificity of ECTA was 94.6% and 88.6%, respectively. Our novel ECTA method showed excellent detection of telomerase activity and is consider applicable as an oral cancer screening system.
Starting Page	38
Ending Page	42
File Size	1136885
Page Count	5
File Format	PDF
ISBN	9781889335490
DOI	10.1109/WAC.2014.6935647
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2014-08-03
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	TSI Press
Subject Keyword	Cancer Surgery Lesions Dentistry Sensitivity and specificity Educational institutions Electrodes assay telomerase oral cancer screening electrochemical
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Electrochemical telomerase assay for screening for oral cancer.

PDT for oral precancerous lesions

Microfluidic electrochemical detection of prostate cancer using telomerase activity (2010).

Evaluation of Turkish dentists’ knowledge about oral cancer and oral mucosal lesions

Detection and Screening of Oral Cancer and Pre-cancerous Lesions

Protocol for diagnostic test accuracy study: the efficacy of screening for common dental diseases by Dental Care Professionals

PULMONARY NODULE CLASSIFICATION: SIZE DISTRIBUTION ISSUES

Oral Bacterial Acid–Base Metabolism in Caries Screening: A Proof-Of-Concept Study

Oral cancer screening practices of oral health professionals in Australia

Electrochemical telomerase assay for oral cancer screening

Similar Documents

Electrochemical telomerase assay for screening for oral cancer.

PDT for oral precancerous lesions

Microfluidic electrochemical detection of prostate cancer using telomerase activity (2010).

Evaluation of Turkish dentists’ knowledge about oral cancer and oral mucosal lesions

Detection and Screening of Oral Cancer and Pre-cancerous Lesions

Protocol for diagnostic test accuracy study: the efficacy of screening for common dental diseases by Dental Care Professionals

PULMONARY NODULE CLASSIFICATION: SIZE DISTRIBUTION ISSUES

Oral Bacterial Acid–Base Metabolism in Caries Screening: A Proof-Of-Concept Study

Oral cancer screening practices of oral health professionals in Australia

Electrochemical telomerase assay for oral cancer screening