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Ventral tegmental area-basolateral amygdala-nucleus accumbens shell neurocircuitry controls the expression of heroin-conditioned immunomodulation
| Content Provider | Semantic Scholar |
|---|---|
| Author | Szczytkowski, Jennifer L. Fuchs, Rita A. Lysle, Donald T. |
| Copyright Year | 2011 |
| Abstract | The present investigations sought to determine whether the ventral tegmental area (VTA), basolateral amygdala (BLA), and nucleus accumbens shell (NAC) comprise a circuitry that mediates heroin-induced conditioned immunomodulation. Rats were given conditioning trials in which they received an injection of heroin upon placement into a distinctive environment. Prior to testing, rats received unilateral intra-BLA microinfusion of a D(1) antagonist concomitantly with unilateral intra-NAC shell microinfusion of an NMDA antagonist. Disconnection of the VTA-BLA-NAC circuit impaired the ability of the heroin-paired environment to suppress lipopolysaccharide-induced immune responses, defining for the first time a specific neural circuit involved in conditioned neural-immune interactions. |
| Starting Page | 47 |
| Ending Page | 56 |
| Page Count | 10 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/j.jneuroim.2011.06.002 |
| PubMed reference number | 21722970 |
| Journal | Medline |
| Volume Number | 237 |
| Alternate Webpage(s) | http://donlysle.web.unc.edu/files/2013/11/Szczytkowski-Fuchs-Lysle-2011-Ventral.pdf |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/S0165572811001627 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/S0165572811001627?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/j.jneuroim.2011.06.002 |
| Journal | Journal of Neuroimmunology |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
