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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Kapadia, V. Houjin Huang Pierstorff, E. Chen, M. Dean Ho |
| Copyright Year | 2008 |
| Description | Author affiliation: Dept. of Biomed. Eng., Northwestern Univ., Evanston, IL (Kapadia, V.) |
| Abstract | Magnetic nanoparticles and carbon nanotubes have both attained a large amount of focus due to their versatile properties and numerous applications. Thus, interfacing magnetic nanoparticles with carbon nanotubes would generate a class of functional materials with broad potential towards nanoscale medicine. Here, a novel method is discussed of incorporating magnetic nanoparticles (iron oxides) onto carbon nanotubes (IONs+CNTs) as well as applying these IONs+CNTs as therapeutic strategies to promote targeted necrosis in cells which may be relevant towards directed cancer therapy, as well as antibacterial/viral applications. To determine the applicability of the IONs+CNTs, we investigated their effects on the expression of cytokines that regulate cellular stress and inflammation from in vitro RAW 264.7 macrophage cell line growth with the IONs+CNTs. In addition, we performed several characterization trials to confirm the presence of a IONs+CNTs interfacing including infrared spectroscopy and scanning electron microscopy. Moreover, we evaluated the effects of applying a magnetic field towards cells that internalized the IONs+CNTs through microscopic imagery. Furthermore, we exposed the IONs+CNTs to an external rotating magnetic field to determine its applicability to aid in directed cell death. The materials/applications realized through this study may provide an efficient method of producing IONs as well as a novel method towards directed cell death that could be implemented in both the fundamental and translational fields. |
| Starting Page | 1119 |
| Ending Page | 1123 |
| File Size | 357748 |
| Page Count | 5 |
| File Format | |
| ISBN | 9781424419074 |
| DOI | 10.1109/NEMS.2008.4484514 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2008-01-06 |
| Publisher Place | China |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Nanoparticles Carbon nanotubes Magnetic materials Biomedical imaging Focusing Magnetic properties Organic materials Iron Cancer Medical treatment Magnetic Spin Carbon Nanotubes Iron Oxide Water Soluble Nanotechnology Necrosis Therapeutic Nanomaterials |
| Content Type | Text |
| Resource Type | Article |
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