NDLI: Micromachined biosensor system for interstitial fluid sampling and glucose monitoring

Content Provider	IEEE Xplore Digital Library
Author	Yaxin Liu Bo Huang Yufeng Yao
Copyright Year	2012
Description	Author affiliation: State Key Laboratory of Robotics and System, Harbin Institute of Technology, Harbin 150001, China (Yaxin Liu; Bo Huang; Yufeng Yao)
Abstract	Continuous blood glucose monitoring is critically important for people with diabetes mellitus. In this paper, considering the long-term, flexible blood glucose monitoring demand, a biosensor system for interstitial fluid (ISF) ultrafiltration sampling and on-line monitoring of blood glucose is presented. The sensor system mainly consists of microfluidics base, silicon glucose sensor chip, and pressure supply module. It could harvest sufficient ISF quickly for glucose monitoring and discharge the used ISF after each measurement. The silicon glucose sensor chip is provided with diffusion control of the analyte through a porous silicon membrane into a silicon etched cavity containing the agarose immobilised enzyme. Experimental results show that the sensor system meets the needs of flexible ISF sampling, and its signal response time at increasing glucose concentrations is about 5s; The linear range is large enough to cover the required broad area of blood glucose (0.2 ∼ 20 mmol/L), the sensitivity is 9.76 nA/mmol. L−1, and the correlation coefficient is 0.9954. This glucose sensor chip has better reliability and stability, and it is easier to integrate into the sensor system for ISF sampling and subsequent glucose monitoring.
Starting Page	647
Ending Page	652
File Size	276747
Page Count	6
File Format	PDF
ISBN	9781467312752
e-ISBN	9781467312783
DOI	10.1109/ICMA.2012.6283218
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2012-08-05
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Sugar Valves Silicon Monitoring Cavity resonators Fluids Electrodes sensor Blood glucose interstitial fluid (ISF) MEMS
Content Type	Text
Resource Type	Article

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