NDLI: Toward development of nano-materials composed of artificial proteins and nano-carbons

Content Provider	IEEE Xplore Digital Library
Author	Kase, D. Shiba, K. Jin Zhu Kasuya, D. Yudasaka, M. Iijima, S.
Copyright Year	2003
Description	Author affiliation: Dept. of Protein Eng., Japanese Found. for Cancer Res., Tokyo, Japan (Kase, D.; Shiba, K.)
Abstract	Fusion materials composed of proteins and nanostructured carbons have a significant potential in various fields including pharmaceuticals, semiconductor technology and material engineering. For example, the internal space of single-wall carbon nanohorns (SWNHs) can be used as a new tool for a drug delivery system (DDS) or a noninvasive imaging system in which proteins would endow biocompatibility and organ specificities to the nanostructured carbons. To translate these potential capacities of the SWNHs into practical applications in the medical area, it is necessary to create artificial proteins that specifically bind to SWNHs and carry the desired biological function(s). In this presentation, we will describe our efforts to develop protein and nano-carbon hybrid materials using our newly established MolCraft methodology. With MolCraft, a single microgene is first designed so that a number of functional motifs would be coded by different coding frames, and then the designer microgene is polymerized in a head-to-tail manner to create repetitious artificial genes. The resultant microgene polymers produce proteins that are combinatorial polymers of embedded functional motifs, among which functional clones are selected. As the first step in the construction of fusion materials composed of protein and SWNHs, we have selected peptide motif, from peptide-display phage libraries that specifically recognize SWNHs. By embedding the determined motif into a microgene, several artificial proteins have been created by MolCraft.
Sponsorship	IEEE Nanotechnol. Council IEEE Region 6 Western USA
Starting Page	386
Ending Page	389
File Size	361611
Page Count	4
File Format	PDF
ISBN	0780379764
DOI	10.1109/NANO.2003.1231799
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2003-08-12
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Protein engineering Nanobioscience Nanostructured materials Polymers Organic materials Semiconductor materials Space technology Biological materials Pharmaceutical technology Drug delivery
Content Type	Text
Resource Type	Article

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