NDLI: Design considerations of cold atmospheric plasma sources for treatment of living tissues

Content Provider	IEEE Xplore Digital Library
Author	Kong, M.G. Walsh, J.L. Cao, Z. Iza, F.
Copyright Year	2010
Description	Author affiliation: Department of Electronic and Electrical Engineering, Loughborough University, Leicestershire, UK (Kong, M.G.; Walsh, J.L.; Cao, Z.; Iza, F.)
Abstract	This presentation provides a summary of current options of cold atmospheric plasma sources as intended for medical applications, in particular treatment of large infected skins. The summary is based on a common base of plasma-cell interactions but addressing the challenge of uneven and complex structures that are commonly found in human chronic wounds. Appropriate cold atmospheric plasma sources must satisfy simultaneous needs for efficacy (effective against microorganisms), accessibility (delivering plasma agents to infected sites specifically), and selectivity (causing little or no damages to health cells and tissues). The impact of plasma-generated reactive oxygen species (ROS), reactive nitrogen species (RNS), electrons and ions, and photons on living cells and tissues triggers a complex sequence of cellular responses, which in turn trigger cellular and intracellular release of ROS and RNS. What happens when plasma molecules meet biomolecules of the cells (e.g. proteins, DNA)? How do they manifest in clinical symptoms? And what science could help to make the meeting between plasma-generated molecules and biomolecules a beneficial one? The exponentially rapid development of plasma-based therapies offers an exciting prospect, but also heightens the urgency for an hitherto unavailable scientific underpinning at a molecular level. We will review lessons from free radical biology and radiation biology, and will evaluate plasma chemistry in an attempt to find ways that could be used to influence plasma-cell interactions in an informed fashion. This will be used to discuss possible requirements for future plasma source designs.
Starting Page	1
Ending Page	1
File Size	124110
Page Count	1
File Format	PDF
ISBN	9781424454747
ISSN	07309244
e-ISBN	9781424454761
e-ISBN	9781424454754
DOI	10.1109/PLASMA.2010.5534050
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2010-06-20
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Plasma sources Plasma chemistry Medical treatment Molecular biophysics Medical services Biomedical equipment Skin Plasma applications Humans Wounds
Content Type	Text
Resource Type	Article
Subject	Atomic and Molecular Physics, and Optics Condensed Matter Physics Electrical and Electronic Engineering

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