NDLI: Neutron Spectroscopy of Mouse Using Neutron Stimulated Emission Computed Tomography (NSECT)

Content Provider	IEEE Xplore Digital Library
Author	Kapadia, A.J. Sharma, A.C. Tourassi, G.D. Bender, J.E. Crowell, A.S. Kiser, M.R. Howell, C.R. Floyd, C.E.
Copyright Year	2006
Description	Author affiliation: Dept. of Biomed. Eng., Duke Univ., Durham, NC (Kapadia, A.J.; Sharma, A.C.)
Abstract	Neutron spectroscopy is evolving as a non-invasive technique to measure element concentration in biological tissue. We have developed a neutron stimulated emission computed tomography (NSECT) system that maps the elemental composition of a body through a non-invasive scan. A neutron beam incident on a sample energizes the sample's atomic nuclei through inelastic scatter interactions. These energized nuclei then spontaneously return to their ground energy states emitting the extra energy as a characteristic gamma photon. An energy-sensitive gamma detector is used to detect this energy and hence identify the emitting atom. Such a technique has several applications in both humans and small animals. Here we demonstrate NSECT's feasibility in scanning small animals, and show results from a spectroscopic examination of a fixed mouse specimen. The mouse was flushed with saline and fixed using a gadolinium/formalin solution. Scanning was performed using a 5 MeV monochromatic neutron beam. Background was corrected using time-of-flight correction to reduce time-uncorrelated noise and polynomial curve-fit subtraction to remove the residual underlying background. The emitted gammas were measured using a high purity germanium (HPGe) clover detector. The resulting spectrum shows various peaks corresponding to elements expected in this specimen such as C, Ca and Gd, several other potential matches such as K and Zn, as well as some system related elements such as Fe, Al and Ge from the detector. This experiment demonstrates the ability of NSECT to obtain element information from an intact small animal specimen through a single non-invasive scan.
Starting Page	3546
Ending Page	3548
File Size	271796
Page Count	3
File Format	PDF
ISBN	1424405602
ISSN	10957863
DOI	10.1109/NSSMIC.2006.353764
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2006-10-29
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Neutrons Spectroscopy Mice Stimulated emission Computed tomography Gamma ray detection Gamma ray detectors Animals Particle beams Biological tissues
Content Type	Text
Resource Type	Article

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