NDLI: Dosimetry in 131I internal emitter therapy using voxel dependent integrated time-activities derived from multiple, registered SPECT and CT images

Content Provider	IEEE Xplore Digital Library
Author	Wilderman, S.J. Avram, A.M. Kritzman, J. Ackerman, R. Dewaraja, Y.K.
Copyright Year	2006
Description	Author affiliation: Michigan Univ., Ann Arbor, MI (Wilderman, S.J.; Avram, A.M.; Kritzman, J.; Ackerman, R.; Dewaraja, Y.K.)
Abstract	The accuracy of dosimetry calculations in internal emitter therapy applications is often limited by a lack of data describing the time dependence of the spatial activity concentration in patients. In many cases, time-dependent activity data is acquired only for specific regions of interest (ROIs), and measurements of patient anatomy and 3D activity distributions are made at only single time points during tracer studies. When calculating absorbed dose in these applications, this scarcity of data necessitates the approximation that activity distributions can be wholly defined by single spatial measurements, and that all points within given ROIs exhibit uniform time dependence. In the current work, CT and SPECT images have been acquired using a dual-modality scanner at multiple time points after administration of both tracer and therapy activity to follicular lymphoma patients being treated with $^{131}I$ tositumomab. The data has been registered to a single CT image, and the mutually registered SPECT images have been used to derive integrated time-activities on a voxel-by-voxel basis. Maps of integral time-activity have been used in conjunction with CT images to determine 3D absorbed dose distributions by Monte Carlo computation. Results are presented illustrating the differences between calculations of spatial distributions of integrated activities and absorbed doses made with the current technique and those performed with previous methods.
Starting Page	3492
Ending Page	3496
File Size	177680
Page Count	5
File Format	PDF
ISBN	1424405602
ISSN	10957863
DOI	10.1109/NSSMIC.2006.353753
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2006-10-29
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Dosimetry Medical treatment Computed tomography Neoplasms Distributed computing Anatomy Time measurement Nuclear and plasma sciences Accuracy Monte Carlo methods
Content Type	Text
Resource Type	Article

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