NDLI: A Large Volume PET Scanner for Low Dose Applications

Content Provider	IEEE Xplore Digital Library
Author	Jakoby, B.W. Townsend, D.W. Sibomana, M. LeBlanc, A.K. Daniel, G.B.
Copyright Year	2006
Description	Author affiliation: Siemens Molecular Imaging, Knoxville, TN (Jakoby, B.W.)
Abstract	A large field-of-view (FOV) LSO PET scanner (Siemens Molecular Imaging) has been investigated for low dose applications. Five panels of dimension 52 cm (axial) times 37 cm (transaxial) comprise 350 detector blocks, each incorporating a 12 times 12 matrix of 4 times 4 times 20 $mm^{3}$ elements. Emission and transmission data are acquired simultaneously while the panels rotate at 30 rpm. This design, with a spatial resolution of 4.5 mm and a sensitivity of 2.3%, is particularly appropriate for applications where a large FOV (52 cm axial, 70 cm transaxial) and low levels of injected radioactivity are essential. The scanner is ideally suited for translational research using animals as models for human disease. The extended patient port facilitates the imaging of larger animals such as dogs that cannot be imaged with a microPET scanner. The large axial FOV and dynamic data acquisition allows multi-organ kinetics to be followed. Animals with natural occurring tumors can be imaged and response to radiation or chemo-therapy followed. The device is also suitable for assessing the functional status of premature infants, beyond just the basic monitoring of respiration and heart beat. A premature infant can be imaged dynamically without removal from the cradle or incubator in a single bed position after injection of very low levels of $^{18}F-FDG.$ This paper will present imaging studies performed with low injected doses, including multi-organ kinetics of both pre-clinical and clinical subjects.
Starting Page	3100
Ending Page	3101
File Size	349819
Page Count	2
File Format	PDF
ISBN	1424405602
ISSN	10957863
DOI	10.1109/NSSMIC.2006.356530
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2006-10-29
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Positron emission tomography Animals Kinetic theory Pediatrics Molecular imaging Detectors Spatial resolution Humans Diseases Dogs
Content Type	Text
Resource Type	Article

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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