NDLI: Comparison of LROC and Traditional ROC Studies for Lesion-Detection Task

Content Provider	IEEE Xplore Digital Library
Author	Si Chen Volokh, L. Chi Liu Tsui, B.M.W.
Copyright Year	2006
Description	Author affiliation: Dept. of Radiol., Johns Hopkins Med. Institutions, Baltimore, MD (Si Chen)
Abstract	The goal of this study is to evaluate lesion detectability in In-111 ProstaScintreg SPECT with different image reconstruction methods using receiver operating characteristic (ROC) techniques of traditional signal position known exactly (SPKE) settings and two other different settings. We generated 3D NCAT phantoms with different body sizes, organ uptake ratios, lesion sizes and lesion contrasts to simulate variations found in a patient population. Monte Carlo methods were then used to generate projection data. The projections were reconstructed using the OS-EM algorithm with different compensations including attenuation compensation (AC), AC and scatter compensation (SC) and AC, SC and collimator-detector response compensation (CDR). We used the channelized Hotelling observer (CHO) for all the 3 settings of ROC studies. The area under ROC curves (AUC) was used as the figure of merit to optimize the updates number and postfilter cut-off frequency of OS-EM with different compensations and then compare the optimized methods. The results show that all 3 different settings of ROC study give consistent results for comparing optimized OS-EM with different compensations. ROC setting 2, which involves localization uncertainty and nonlinear combination of body size variations have better statistical power than the SPKE setting (setting 1). The AUC of CHO in ROC setting 2 and 3 are significantly lower than that of setting 1 which may predict better the human observers' performances in clinical trials.
Starting Page	2072
Ending Page	2075
File Size	486926
Page Count	4
File Format	PDF
ISBN	1424405602
ISSN	10957863
DOI	10.1109/NSSMIC.2006.354321
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2006-10-29
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Lesions Image reconstruction Optimization methods Imaging phantoms Attenuation Scattering Collimators Cutoff frequency Uncertainty Humans
Content Type	Text
Resource Type	Article

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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