NDLI: Simultaneous Dual Tracer PET Using Generalized Factor Analysis of Dynamic Sequences

Content Provider	IEEE Xplore Digital Library
Author	El Fakhri, G. Sitek, A. Guerin, B.
Copyright Year	2006
Description	Author affiliation: Harvard Med. Sch., Boston, MA (El Fakhri, G.)
Abstract	Simultaneous dual tracer PET imaging has potential for simultaneous assessment of two physiological processes under identical conditions, but it has not been successfully achieved in the clinical setting because of the lack of potential for energy discrimination. We developed a new approach based on generalized factor analysis of dynamic sequences (GFADS) that exploits temporal differences between radiotracers and applied it to the case of simultaneous imaging of brain metabolism and dopamine transporter density (DAT) using $^{18}FDG$ and $^{18}FECNT.$ Monte Carlo simulations of both studies were performed in a population of anthropomorphic phantoms using 5 different specific and non-specific DAT time activity curves (TAC) previously reported in human and monkey studies. 3D acquisitions were simulated while modeling random and scatter coincidences as well as pixelated block detectors, light sharing among crystals elements and dead-time in the PET/CT scanner. Activity distributions of $^{18}FDG$ as well as specific and non-specific $^{18}FECNT-DAT$ were simulated separately and 25 dynamic simultaneous dual tracer studies were generated. We found very good agreement between the estimated GFADS factors and the simulated reference TACs, and between the GFADS factor images and the corresponding reference activity distributions with errors less than 7.3 plusmn 1.3%. Biases in estimation of specific DAT binding and relative metabolism activity were within 5.9 plusmn 3.6% compared to the reference values.
Starting Page	2128
Ending Page	2130
File Size	434286
Page Count	3
File Format	PDF
ISBN	1424405602
ISSN	10957863
DOI	10.1109/NSSMIC.2006.354334
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2006-10-29
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Positron emission tomography Image sequence analysis Biochemistry Potential energy Image analysis Anthropomorphism Imaging phantoms Humans Light scattering Crystals
Content Type	Text
Resource Type	Article

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