NDLI: Fast Monte Carlo Simulation Based Joint Iterative Reconstruction for Simultaneous 99mTc/123I Brain SPECT Imaging

Content Provider	IEEE Xplore Digital Library
Author	Jinsong Ouyang El Fakhri, G. Moore, S.C. Kijewski, M.F.
Copyright Year	2006
Description	Author affiliation: Dept. of Radiol., Harvard Med. Sch., Boston, MA (Jinsong Ouyang; El Fakhri, G.; Moore, S.C.; Kijewski, M.F.)
Abstract	Simultaneous $^{99m}Tc/^{123}I$ SPECT allows assessment of two functions under identical physiological conditions. Separation of these isotopes is difficult, however, because their energies are close. Most correction methods do not fully model either physical effects or patient-specific activity and attenuation distributions, and often reject scattered photons, rather than using the information they carry. We have developed a fast Monte Carlo (MC) simulation-based multiple-isotope and multiple-energy joint ordered-subset expectation maximization (JOSEM) iterative reconstruction algorithm, MC-JOSEM, that simultaneously corrects for scatter and crosstalk. We evaluated MC-JOSEM for simultaneous brain perfusion $(^{99m}Tc-HMPAO)$ and neurotransmission $(^{123}I-altropane)$ SPECT. MC simulations of $^{99m}Tc$ and $^{123}I$ studies were generated separately and then combined to mimic simultaneous $^{99m}Tc/^{123}I$ SPECT. All details of photon transport through the brain, the collimator, and detector, including Compton and coherent scatter, septal penetration and backscatter from components behind the crystal, were modeled. We reconstructed images from simultaneous dual-isotope projections in two ways. First, we reconstructed the photopeak-energy-window projections (with an asymmetric energy window for $^{123}I)$ using the standard ordered subsets expectation maximization algorithm (AW-OSEM). Second, we reconstructed the 3-energy-window projections using a MC based iterative reconstruction that we have developed (MC-JOSEM). After fifteen iterations of reconstruction of $^{99m}Tc$ images, root mean square errors (RMSE) of activity estimates in several brain structures from MC-JOSEM were reduced by 79-94% compared to AW-OSEM in the thalamus, striata, white matter, and gray matter. Similarly, RMSE of activity estimates from $^{123}I$ images reconstructed by fifteen iterations of MC-JOSEM were reduced by 30-58% compared to AW-OSEM in the striata and background.
Starting Page	2251
Ending Page	2256
File Size	367812
Page Count	6
File Format	PDF
ISBN	1424405602
ISSN	10957863
DOI	10.1109/NSSMIC.2006.354362
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2006-10-29
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Image reconstruction Electromagnetic scattering Particle scattering Brain modeling Single photon emission computed tomography Photonic crystals Isotopes Attenuation Monte Carlo methods Reconstruction algorithms
Content Type	Text
Resource Type	Article

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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