NDLI: Investigation of image quality and NEC in a TOF-capable PET scanner

Content Provider	IEEE Xplore Digital Library
Author	Surti, S. Karp, J.S. Popescu, L.M. Daube-Witherspoon, M.E. Werner, M.
Copyright Year	2004
Description	Author affiliation: Dept. of Radiol., Pennsylvania Univ., Philadelphia, PA (Surti, S.; Karp, J.S.; Popescu, L.M.; Daube-Witherspoon, M.E.; Werner, M.)
Abstract	The purpose of this work is to determine the benefit which can be achieved in image quality for a time-of-flight (TOF) capable 3D whole-body PET scanner. We simulate a 3D whole-body time-of-flight PET scanner with a complete modeling of spatial and energy resolutions. The simulated scanner has a diameter of 84-cm, an axial FOV of 25-cm, and uses a $4times4times30-mm^{3}$ pixelated $LaBr_{3}$ Anger-logic detector. Multiple simulations were performed for a 27-cm diameter and 70-cm long uniform cylinder with hot spheres (22,17,13, and 10-m diameter) in central slice, and 10-mm diameter hot spheres in a slice at 1/4 axial FOV (8:1 activity uptake ratio with respect to background). Image reconstruction was performed with a list-mode iterative TOF algorithm and data were currently analyzed for true coincidences after attenuation correction for timing resolutions of 300,600,1000-ps and non-TOF. Our results show that contrast recovery improves with TOF (NEMA NU2-2001 analysis). Detectability for 10-mm diameter hot spheres estimated using a non-prewhitening matched filter (NPW SNR) also improves with TOF and best results are obtained for timing resolution les300 ps
Starting Page	4032
Ending Page	4037
File Size	1244878
Page Count	6
File Format	PDF
ISBN	0780387007
ISSN	10823654
e-ISBN	0780387015
DOI	10.1109/NSSMIC.2004.1466780
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2004-10-16
Publisher Place	Italy
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Image quality National electric code Positron emission tomography Whole-body PET Timing Energy resolution Detectors Image reconstruction Iterative algorithms Data analysis
Content Type	Text
Resource Type	Article

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