NDLI: Relative lesion detectability in 3D vs. 2D dedicated multi-ring PET

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1999 IEEE Nuclear Science Symposium. Conference Record. 1999 Nuclear Science Symposium and Medical Imaging Conference (Cat. No.99CH37019)

1998 IEEE Nuclear Science Symposium Conference Record. 1998 IEEE Nuclear Science Symposium and Medical Imaging Conference (Cat. No.98CH36255)

1997 IEEE Nuclear Science Symposium Conference Record

1996 IEEE Nuclear Science Symposium. Conference Record

Relative lesion detectability in 3D vs. 2D dedicated multi-ring PET

Content Provider	IEEE Xplore Digital Library
Author	Moore, S.C. El Fakhri, G. Badawi, R.D. Van den Abbeele, A.D. Zimmerman, R.E.
Copyright Year	2000
Description	Author affiliation: Dept. of Radiol., Brigham & Women's Hospital, Boston, MA, USA (Moore, S.C.)
Abstract	The authors estimated the detectability of spheres of different sizes but equal activity contrast, embedded in a clinically realistic phantom in order to compare two-dimensional (2D) and three-dimensional (3D) whole-body (WB) PET imaging for a relevant diagnostic task. Five plastic spheres with inside diameters of 0.8 to 3.4 cm, containing 74 kBq/ml of Ge-68, were placed in an anthropomorphic torso phantom. The background organs contained F-18 activity concentrations in appropriate physiologic proportions, as did a head phantom positioned outside the field of view (FOV) of the authors' ECAT-HR+ system. The phantom was scanned for 9 hours at 1 bed position as the F-18 decayed from 97 to 3.2 kBq/ml. The authors obtained 10, 1-minute scans for each activity contrast level, alternating among 3 acquisitions: 2D mode with standard maximum ring difference (MRD=7), standard 3D mode (MRD=22), and 3D mode with MRD=13 (3D). Images from 2D and 3D acquisitions were reconstructed by filtered backprojection and 3D reprojection (3DRP); 3D data were also reconstructed by FBP after Fourier rebinning (FORE+FBP). Sphere detectability was estimated using non-prewhitening (NPW) matched filtering to compute the detection signal-to-noise ratio, NPW SNR. In almost all cases, NPW-SNR was greater for 3D or 3D than for 2D, although 2D outperformed 3D with 3DRP reconstruction at the earliest time points for 2 spheres located near opposite ends of the axial FOV; FORE+FBP reconstruction significantly improved the detectability of these spheres, compared to 3DRP, and demonstrated the expected near equivalence of 3D and 3D* data from spheres near the ends of the FOV. The authors' results were not predictable from global NEC considerations alone.
File Size	575988
File Format	PDF
ISBN	0780365038
ISSN	10823654
DOI	10.1109/NSSMIC.2000.949192
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2000-10-15
Publisher Place	France
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Lesions Positron emission tomography Imaging phantoms Image reconstruction Whole-body PET Plastics Anthropomorphism Torso Head Matched filters
Content Type	Text
Resource Type	Article

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