NDLI: A Breast Phantom Lesion Study With the High Resolution Transformable HOTPET Camera

Content Provider	IEEE Xplore Digital Library
Author	Baghaei, H. Hongdi Li Yuxuan Zhang Ramirez, R.A. Chao Wang Shaohui An Shitao Liu Wai-Hoi Wong
Copyright Year	1963
Abstract	The high-resolution oncologic transformable PET (HOTPET) camera can operate in different modes including breast mode and whole-body mode. In the whole-body mode, HOTPET has a transverse field-of-view (FOV) of 60 cm and an axial FOV of 13 cm. In the breast mode it has a transverse FOV of 39 cm and an axial FOV of 21 cm. The aim of this study was to compare the performance of the two modes of HOTPET for observation of small ( <; 10 mm) breast lesions to measure the effective gain in lesion detection by using a dedicated breast ring PET. We compared the two modes of camera by scanning a breast phantom with small lesion insert. The breast phantom was attached to an anthropomorphic torso phantom with lung and cardiac inserts. We scanned several small lesions with inner diameters in the range of 3.95 mm to 7.86 mm for several lesion activity contrasts. The ratio of the activity concentration in the lesions to the activity concentration in the breast background ranged from 1 to 10. Reconstructed images of lesions were compared visually and we also compared the image contrast of lesions and radial profiles of lesions. The 7.86-mm lesion was observable for lesion to breast background activity ratio of 2.2 or higher in HOTPET breast mode and for activity ratio of 3.1 or higher in the whole-body mode. The 4.95-mm lesion was observable for activity ratio of 3.1 in the breast mode and activity ratio of 6.9 in whole-body mode. The 3.95-mm lesion was visually observable for activity ratio of higher than 5 in the breast mode but it was not observable in whole-body mode even at the highest measured contrast. This study demonstrated that a whole-body PET camera such as HOTPET even with 2.9-mm spatial resolution may not be able to detect lesions smaller than 7 mm for lesion to background activity ratio 3.5, while a dedicated full ring breast PET similar to HOTPET breast mode could detect smaller lesions (≤ 5 mm) for similar uptake.
Sponsorship	IEEE Nuclear and Plasma Sciences Society Computer Applications in Nuclear and Plasma Sciences (CANPS) Lawrence Berkeley Lab. Lawrence Livermore Nat. Lab. APS College of William and Mary Continuous Electron Beam Accelerator Facility NASA Defence Nuclear Agency Sandia National Laboratories Jet Propulsion Laboratory Brookhaven Nat. Lab. Lawrence Livermore Nat. Lab IEEE/NPPS Radiat. Effects Committee Defence Nuclear Agency/DoD Sandia National Laboratories/DOE Jet Propulsion Laboratory/NASA Phillips Lab./DoD
Starting Page	2504
Ending Page	2509
Page Count	6
File Size	2549422
File Format	PDF
ISSN	00189499
Volume Number	57
Issue Number	5
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2010-10-01
Publisher Place	U.S.A.
Access Restriction	One Nation One Subscription (ONOS)
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Breast Imaging phantoms Lesions Cameras Whole-body PET Gain measurement Performance gain Positron emission tomography Anthropomorphism Torso positron emission tomography (PET) Breast imaging HOTPET lesion detection
Content Type	Text
Resource Type	Article
Subject	Nuclear and High Energy Physics Electrical and Electronic Engineering Nuclear Energy and Engineering

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
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7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
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9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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