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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Nuzzo, S. Peyrin, F. Martin-Badosa, E. Lafage-Proust, M.H. Boivin, G. |
| Copyright Year | 2000 |
| Description | Author affiliation: Eur. Synchrotron Radiat. Facility, Grenoble, France (Nuzzo, S.) |
| Abstract | Synchrotron Radiation /spl mu/CT (SR /spl mu/CT) may provide 3D images with spatial resolution as high as one micrometer. The SR /spl mu/CT system developed at ESRF was already used to quantify trabecular bone architecture in bone samples. In this work we propose for the first time to use SR /spl mu/CT to assess the mineral content in bones. This quantification is possible thanks to the monochromaticity and high photon flux of the X-ray beam extracted from synchrotron radiation. For this purpose, we relate the reconstructed gray levels of the images to a degree of mineralization in bone. We propose a calibration method to estimate the 3D distribution of hydroxyapatite concentrations within the sample. This method if compared to a reference microradiography technique. Finally, we illustrate the possibilities of the method on 3D images of human biopsies from osteoporotic patients before and after a treatment with bisphosphonates. |
| File Size | 677779 |
| File Format | |
| ISBN | 0780365038 |
| ISSN | 10823654 |
| DOI | 10.1109/NSSMIC.2000.949264 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2000-10-15 |
| Publisher Place | France |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Minerals Synchrotron radiation Strontium Spatial resolution Cancellous bone X-ray imaging Image reconstruction Mineralization Calibration Humans |
| Content Type | Text |
| Resource Type | Article |
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