NDLI: SIC: an intracerebral radiosensitive probe for in vivo neuropharmacology investigations in small laboratory animals: first prototype design, characterization and in vivo evaluation

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Comparison between an image- and a sinogram-based correction algorithm for partial volume effect in 3D PET imaging

A correction algorithm for partial volume effects in 3D PET imaging: principle and validation

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Simulation studies for the quantitative detection of lesions by statistical parametric mapping in assessing cerebral blood flow with SPECT

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Spectral analysis for evaluation of myocardial tracers for medical imaging

Factor analysis for the quantification of renal cortical blood flow using O-15 water dynamic PET

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Mathematical foundations of phase-contrast computed tomography

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Volume 2 - 2000

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1999 IEEE Nuclear Science Symposium. Conference Record. 1999 Nuclear Science Symposium and Medical Imaging Conference (Cat. No.99CH37019)

1998 IEEE Nuclear Science Symposium Conference Record. 1998 IEEE Nuclear Science Symposium and Medical Imaging Conference (Cat. No.98CH36255)

1997 IEEE Nuclear Science Symposium Conference Record

1996 IEEE Nuclear Science Symposium. Conference Record

SIC: an intracerebral radiosensitive probe for in vivo neuropharmacology investigations in small laboratory animals: first prototype design, characterization and in vivo evaluation

Content Provider	IEEE Xplore Digital Library
Author	Pain, F. Laniece, P. Mastrippolito, R. Pinot, L. Charon, Y. Glatigny, A. Guillemin, M.T. Hantraye, P. Leviel, V. Valentin, M.I.
Copyright Year	2000
Description	Author affiliation: Inst. de Phys. Nucl., Univ. Paris II, Orsay, France (Pain, F.)
Abstract	Several high-resolution tomographs dedicated to small animal imaging are presently under development. However, these devices suffer from two major drawbacks: their cost is high and require animal anaesthesia and immobilization thus restricting the field of investigations. Therefore, the authors have proposed SIC (French acronym for "Sonde IntraCerebrale") a low cost beta microprobe able to count the radioactivity concentration locally in awake, freely moving animals. Beside a good sensitivity, this tool offers the advantage of a high temporal resolution, a major asset for in vivo measurements of tracer kinetics. Furthermore, it could be easily coupled with existing techniques such as electrophysiology, microdialysis, voltametry and magnetic resonance imaging thus providing simultaneously complementary information on the cerebral mechanisms. The authors present here the design, manufacture and first evaluations of a first prototype. A first in vitro evaluation using a simple beaker filled with an homogenous aqueous solution of [/sup 18/F]-fluorodeoxyglucose (FDG) confirmed the authors' first simulation results in terms of sensitivity and detection volume. Then, further experimentation carried out in vivo on anaesthetized rats bearing two implanted probes in the brain have validated the use of SIC to measure locally, with a high temporal resolution, the concentration of radiolabeled molecules in living rodents.
File Size	578729
File Format	PDF
ISBN	0780365038
ISSN	10823654
DOI	10.1109/NSSMIC.2000.949336
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2000-10-15
Publisher Place	France
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Silicon carbide Probes In vivo Animals Costs High-resolution imaging Kinetic theory Couplings Magnetic resonance imaging Manufacturing
Content Type	Text
Resource Type	Article

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