NDLI: Application of factor and cluster analysis for the parametric image of myocardial blood flow using H/sub 2//sup 15/O and dynamic PET

Content Provider	IEEE Xplore Digital Library
Author	Lee, J.S. Ahn, J.Y. Lee, D.S. Seo, K. Park, K.S.
Copyright Year	2000
Description	Author affiliation: Dept. of Nucl. Med. & Biomed. Eng., Seoul Nat. Univ., South Korea (Lee, J.S.)
Abstract	Although the parametric image (PI) of regional myocardial blood flow (rMBF) using H/sub 2//sup 15/O and PET would facilitate the numerical evaluation and the clinical visual interpretation of rMBF, low signal to noise ratio (SNR); of the time activity curve (TAC) of individual voxel in dynamic H/sub 2//sup 15/O PET image has made the composition of PI difficult to accomplish. The authors propose a method for PI of rMBF from H/sub 2//sup 15/O PET using factor analysis and cluster analysis. Factor analysis was performed to extract TACs of the right and left ventricular blood pool and their factor images. The blood pool activity was then subtracted from the original dynamic frames to remove the spillover contamination to myocardial tissue. Pure TACs in myocardial tissue were submitted to cluster analysis for PI of rMBF, which averaged voxels with the same shape TACs to increase SNR of PI and reduce calculation time. Parametric images showed good image quality and contrast in comparison to either the factor images of myocardial tissue or the subtracted imaged composed by subtracting the initial 30 seconds' images from the 2 minutes' ones. RMBF ranged 0.89-1.35 m/min/g at rest, and 1.16-3.85 at stress. Computation time was less than 1 minute on the workstation with 333 MHz CPU.
File Size	541386
File Format	PDF
ISBN	0780365038
ISSN	10823654
DOI	10.1109/NSSMIC.2000.949257
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2000-10-15
Publisher Place	France
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Image analysis Myocardium Positron emission tomography Signal to noise ratio Blood flow Performance analysis Contamination Shape Image quality Stress
Content Type	Text
Resource Type	Article

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